Preventing Lung Scarring May Extend Lives

[RandyW]

Preventing Lung Scarring May Extend Lives Of Lung Cancer Patients

ScienceDaily (Oct. 31, 2007) — Researchers have found that using a special type of drug called a pharmaceutical monoclonal antibody to block the integrin beta6-TGF-beta pathway prevents a serious side effect of radiation therapy for lung cancer patients -- pulmonary fibrosis (scarring of the lungs), thereby extending patients' lives and improving their quality of life, according to a new study.

"The toxicity of pulmonary fibrosis limits the amount of the radiation dose that can be safely given to patients," said Simon Cheng, M.D., Ph.D., an author of the study and a radiation oncologist at New York University Medical Center in New York. "These study results may lead to more effective radiation therapies for advanced lung cancer, which is the leading cause of cancer deaths in the U.S."

More than 50 percent of patients receiving radiation therapy for advanced lung cancer develop radiation-induced lung fibrosis, a painful side effect that can affect patients' quality of life and, in some cases, can be fatal. Pulmonary (lung) fibrosis involves inflammation and scarring of the lungs causing patients to feel short of breath, have a chronic dry cough, feel fatigue and pain in the chest, and suffer loss of appetite and weight loss. Over time, fibrosis causes the air sacs of the lungs to be replaced by scar tissue, causing difficulty breathing and an irreversible loss of the tissue's ability to transfer oxygen into the bloodstream.

This study involved mice treated with a 14 Gy single dose of radiation to the lungs. Researchers wanted to determine if using an antibody to block integrin beta6 (a specific activator of the transforming growth factor (TGF-beta) signaling pathway), could prevent the onset of radiation-induced pulmonary fibrosis. The study shows that mice that were given integrin beta6 monoclonal antibodies did not develop radiation-induced lung fibrosis, while the control group of mice developed the lung condition.

"Fibrosis is a very serious side effect that often keeps doctors from giving patients a full dose of radiation for fear that the serious problems caused by fibrosis will outweigh the good done by the radiation. If further studies conclude that this drug can indeed prevent fibrosis in lung cancer patients, I believe researchers are a huge step closer to curing this disease," said Dr. Cheng.

The abstract, "The Integrin-TGFbeta Axis: Inhibition of Integrin Alphav Beta6 Prevents Radiation-induced Lung Fibrosis," was presented at the Plenary I session on October 29, 2007, at the American Society for Therapeutic Radiology and Oncology's 49th Annual Meeting in Los Angeles on October 29, 2007.

Adapted from materials provided by American Society for Therapeutic Radiology and Oncology.

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American Society for Therapeutic Radiology and Oncology (2007, October 31). Preventing Lung Scarring May Extend Lives Of Lung Cancer Patients. ScienceDaily. Retrieved November 1, 2007, from http://www.sciencedaily.com­ /releases/2007/10/071029121542.htm

[gpawelski]

Avastin has a role in both VEGF and TGF-beta signaling pathways (it is a monoclonal antibody). Here is some very new and interesting information about fighting radiation-induced necrosis with Avastin.

When brain tumors are treated with radiation therapy, there is always a risk of radiation-induced necrosis of healthy brain tissue. Insidious and potentially fatal, radiation necrosis of the brain may develop months or even years after irradiation.

This poorly understood side effect can occur even when the most stringent measures are taken to avoid exposing healthy tissue to harmful levels of radiation. In most cases, radiation necrosis of the brain occurs at random, without known genetic or other predisposing risk factors. The only treatment options typically available for radiation necrosis of the brain are surgery to remove dead tissue and use of the steroid dexamethasone to provide limited symptom control. But clinicians have not found a way to stop the progression of necrosis, despite having tested a range of therapies including anticoagulants, hyperbaric oxygen, and high-dose anti-inflammatory regimens.

However, recent studies at M. D. Anderson have shown that the monoclonal antibody bevacizumab (Avastin) may be able to stop radiation necrosis of the brain and allow some of the damage to be reversed. Victor A. Levin, M.D., a professor in the Department of Neuro-Oncology and the senior researcher on the studies, said the findings suggest that radiation necrosis of the brain can be successfully managed—and perhaps even prevented—with Avastin (bevacizumab) or similar drugs.

While the above study involved mice, the Anderson study involves Avastin treatment for radiation-induced necrosis on human beings. Perhaps Avastin could be a treatment for radiation fibrosis?

http://www2.mdanderson.org/depts/oncolo ... -09-2.html