Deb B Posted April 9, 2018 Share Posted April 9, 2018 Is c-met positive the same as ALK? They both can be treated with Crizotinib. Does Crizotinib kill the cancer or just keep it stable with the TLK inhibitors? Link to comment Share on other sites More sharing options...
Tom Galli Posted April 10, 2018 Share Posted April 10, 2018 Deb, To the best of my knowledge c-MET and ALK are completely different. Anaplastic lymphoma kinase (ALK) rearrangement is an unusual genetic rearrangement. C-MET is a genetic signaling pathway involving the spreading, migration and invasion of cancer cells. Now that is my synthesis of some very complicated journal articles. But, I believe I understand enough to conclude that ALK and c-MET are not similar processes or mutations. Crizotinib is a targeted therapy used for adenocarcinoma that displays ALK rearrangement. It also is effective for those that display c-MET biomarkers. My reading of several journal articles suggests Crizotnib destroys the tumor. But I am not a doctor and I could be wrong. Some of these journal articles are very hard to comprehend so you might want to tee this question up to your medical oncologist. Stay the course. Tom Link to comment Share on other sites More sharing options...
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