I've been on the Gilotrif for two days and so far haven't had side effects. The docs have me on a low dose antibiotic to help with the rash that they tell me will develop. I also expect diarrhea but it hasn't shown up yet. I know there are usually nail and cuticle issues on the hands and feet so I'm using a good moisturizing lotion on both when I go to bed and hope it helps. Other than that I'm hoping I'll be able to function somewhat normally. I'll have a scan in two months to see if it's having any effect. I'll post my experience. I hope it might help someone else in my situation. I know there's a lot of current research in targeted therapy with gene mutations so there is some hope.