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Good Bro

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Good Bro last won the day on July 27

Good Bro had the most liked content!

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    Monroe
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    MICHIGAN
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  1. Good Bro

    Keytruda

    Great to hear Snowmom!!! It really sounds like Keytruda is a miracle drug with maybe better success rates with higher PDL1. Great to hear that it also looks like it works well regardless of PDL levels. Keytruda has been out for many years now. It seems it works better these days though. Rarely hear of cases where it didn't help whatsoever. One would think with drugs like these, the Google stats from 5-10+ years ago would start to improve considerably with 5 year survival rates.
  2. Good Bro

    Keytruda

    My brother (NSCLC Stg4, brain & spine mets, no targetable mutations, neg PDL1, dx 5/'21, age 47) had his first maintenance infusion of Alimta & Keytruda 2 weeks ago. That was after 4 infusions every 3 weeks of the triplet. He has shown some response (regression) in many tumors. Just had targeted radiation on 18 brain tumors last week. Can't wait for the next MRI to see the success of that. Really hoping they are gone so that maybe they will let him drive again. What I am wondering though is the success rate or stories of success with Keytruda for those with no PDL1. Most of what I have read states that Keytruda is most effective for those with higher levels of PDL1. Do any of you who have experienced great success on this drug have very low or negative for PDL1?
  3. Great news Suzanna. If you don't mind me asking, what was Adam's PDL1 levels? Just wondering as my brother's onc has him on the triplet treatment now still. He will have his 5th infusion tomorrow. 1st rescan showed some response to treatment but his 2nd rescan isn't so clear yet. He will discuss with his onc tomorrow before his treatment. His understanding of the report is that maybe mostly stable but maybe with a new met in his hip area. He has mets to his brain and spine, no targetable mutations, and negative PDL1. So, about as grim as it gets for the diagnosis. However, this Keytruda drug really seems to be a miracle drug. So, looking for some stories where it has worked miracles on survivors with no PDL1. Again, congrats to you and Adam on the NED. I am so looking forward to throwing an NED party for my brother some day.
  4. My bro received his second round of the triplet infusion last week with nearly no noticeable side effects this time. The doc did prescribe some steroids for him to take for a few days post treatment. Seems to have worked quite well. He mentioned to me that he thinks he is actually noticing that the treatments may be working. The nagging headaches are subsiding (hopefully that means the brain mets are shrinking), he isn't getting quite as fatigued, and the cough and pains are noticeably better (not gone but better). Doesn't seem to be any increase in his lung capacity yet though. Still gets out of breath quickly. His next CT and MRI scans will be in 3 weeks with another treatment scheduled a couple days after the rescans. Really hoping to see some reduction in the number of brain mets present so that he may be able to get some targeted radiation instead of WBRT. He really wants to get back to driving but the docs won't let him with the presence of the brain mets.
  5. I did confirm that his treatment drugs are the Carboplatin, Altima, Keytruda triplet. I do understand that Targeted Therapy is not part of the treatment regime. Really can't be since no biomarkers were detected. Had biomarkers been detected, they likely would have used Targeted drugs as the first line treatment (their words). I did find out that his PD-L1 expressions was "negative (1-49%)" and his type is nonsquamous. His next (2nd) treatment is the 22nd. Then they will take new scans sometime after that. His cough, fatigue, and shortness of breath, along with a little chest pain, are his main symptoms and as sounds quite common, he has his good days and bad days. Overall though, the symptoms seem to be slowly worsening.
  6. Sorry, I believe it is the Carboplatin. I wrote Cis instead of Carbo. Thinking the 3rd drug is the Altima but need to confirm that one.
  7. Thx Tom. He has a lot of close family helping him out and constantly doing things to keep him out of that dark area. He seems really positive most of the time but as you mentioned, men often hide or even disguise it sometimes. My brother and I are really close and I would hope that I would be able to recognize it. As for his drug combo, I'm not 100% certain (as he isn't either, at least when he talks about it). I know the Keytruda is one and I believe that Cisplatin may have been another. I will see if I can get all the info from him. He had the 18-24hr crash which started 2 days after his treatment. Feels better now though and he said that something feels different in his chest. Can't say it feels "better" but definitely different. He's not sure if that's good or not. My wife's cousin lost her battle with SCLC only 5 months after diagnosis. She was in her mid-50's. This was just a few years back and so my family (including my brother) remember this vividly and it may be driving more sadness than hope is his situation. We know though that SCLC is worse than NSCLC, even in the later stages. These forums though really show how there isn't just hope but how the odds actually seem to be turning in favor of the patient to become a really long term survivor. Wondering from this group though how realistic the newer Brain Mets GPA Index used to generate a general prognosis is? Supposedly, this indexing takes into account the presence of bio markers (at least the EGFR & ALK ones) and the success of the approved treatments for them.
  8. Thank you Tom. Yes, I have shared this forum with him, his wife, and our parents. The real-life accounts shared on here really boosted the family's hope for him and really got him in the offensive attack mindset instead of just the defensive side. The only thing I don't understand in his treatment plan with holding off on the brain radiation is that most of what I read states that most chemo drugs don't make it past the blood-brain barrier and therefore don't do much for brain mets. Also, how quickly do the brain mets grow? Basically, it is going to be 6+ weeks before they even retake more scans to see if the chemo did do anything for the brain mets. If they find that it hasn't done anything for those mets, then it will be 8+ weeks from brain met diagnosis to the first radiation treatment to address them. Just seems long. I know this stuff takes time but we all know that it (time) is the one thing that patients with this nasty disease might not have on their side.
  9. First time posting... My brother, who is in his late 40's, was diagnosed with mNSCLC about a month ago. Unfortunately, he didn't have any of the bio markers evident from his biopsy. Even though it has spread to his brain, the docs have decided to start the chemo/immuno treatments (Triplet, I believe) before doing any radiation for the brain tumors. They are hoping the chemo may eliminate the numerous very small brain lesions so that they can treat the couple larger ones with targeted radiation and not have to conduct a WBRT. Can't believe he has to deal with this late-stage cancer after being a survivor of Hogkins Lymphoma about 25 years ago. Praying that this Triplet concoction performs well for him and he will eventually be able to hear the doctors report... NED!!!
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