KF1

We received the results from my wife's recent PET scan. This was her first scan since starting Tabrecta on 5/12. No new lesions. All nodules, but one, were reduced in size most more than 50%. Metabolic activity was also significantly reduced. She continues to tolerate the Tabrecta well. She is having some ankle swelling but elevating feet for a short period eliminates it. We were very pleased with the results

My wife is now on week 13 of Tabrecta. So far tolerating well. Fatigue and minor stomach issues from time to time. She has also just started getting some swelling in her ankles. Very minor so far and is alleviated by simply raising her feet when relaxing. She also had a follow up brain MRI for numerous brain Mets. This was her first follow up since diagnosis The two large lesions were greatly reduced in size. The 15 minor lesions were gone and there were no new lesions. We are hopeful that the Tabrecta played some role In this since she also had WBRT in April She has her first PET scan next week since starting Tabrecta in May. Keeping our fingers crossed

A setback for my wife. She unfortunately has contracted COVID, despite being vaxed and boosted, and had to be hospitalized due to low O2 levels. She appears to be on the mend. She has been on low flow supplemental oxygen and they debated releasing her today. However the infectious disease doc wanted her to complete the 5 courses of remdesivir. Hopefully if she continues to improve she will be out Thursday. My concern is that they stoped the the Trabecta while dealing with COVID. I hope that she will be able to restart as soon as she clears the COVID virus. I was wondering if any of Trabecta users have had to deal with this.

Thanks for that heads up. I had checked their site and it was where I became aware of the MET docs there.

Brief update re: my wife. Has been on Trabecta for 15 days. As of now periodic fatigue appears to be the sole side effect. Will have f/u PET following 3 months of treatment. She has had significant hair loss as a result of her WBRT. Brain MRI scheduled for later this summer to assess efficacy of brain radiation. Keeping our fingers crossed that she continues to tolerate the Trabecta well. We both like her current Oncologist. However we are setting up a second opinion at Moffit in Tampa. They apparently have a couple of docs there who specialize in the MET mutation that she has. So now it is sit back and wait.

Met with the oncologist yesterday to go over PET and biomarker results. It was a positive meeting. PET indicates mass in lower right lung lobe, lymph involvement primarily within the hilarity and mediastinal region. One small spot in right shoulder blade. Her cancer actually has 2 bio markers. Met exon 14 skipping and PD-L1. She will starting with Tabrecta as her first line treatment. Tabrecta can also apparently cross the blood-brain barrier so may have some impact in eliminating any residual brain mets. Its amazing to me that she had no symptoms until the neurological ones. She had ten lesions in brain.

Hi my name is Kevin. My wife Dale (69) was diagnosed with NSCLC adenocarcinoma in the past two weeks. First symptoms were neurological. We were devastated when told by the ER doc that she had metastatic brain cancer. Further work up indicated lung cancer. Had a PEt scan last Monday and currently waiting on results from bio marker study. We have a meeting with oncologist this Thursday. She just completed radiation therapy for brain lesions. Glad I found this forum.