GBean

Your results are so refreshing! I am very happy to hear Tagrisso has worked so well for you! My husband has NSCLC EGFR Exon 19 Del with Brain Mets (adenocarcinoma). Can you share what dosage you are on? My husband is on 120mg, however his doctor wants him to the max does of 160mg to penetrate his brain mets. Thank you!

Might I ask what dose you are all at? My husband is at 120mg and doctor wants him up to 160mg for BBB penetration due to brain mets. Thanks in advance! All the best to all of you warriors!

Hello...I am reading your story. Your wife and you are troopers! My husband also has EGFR exon 19 del and was diagnosed with stage 1b lung cancer back in 2021. This past January 2023, he ended up in ER with seizure to later find out that he had Stage IV Brain Mets from his NSCLC. They resected one brain tumor, however about 11 remain. He has had 15 days WBRT and has been on Tagrisso since Mid February. He has adenocarcinoma type. Might I ask the dosage of Tagrisso your wife is on? My husband is at 120mg, however doctor wishes for him to get to the max dose of 160mg for full brain penetration. He just can't handle the increase just yet. He is very fatigued and I don't know if it is from the Tagrisso, the radiation, or the cancer. I will check out the trial you mentioned. I have read many of the FLAURA articles and research. Some help but some do not. Hang in there Ace!

Hi Tom, that is wonderful news! So glad you are doing well! Great hope! His is adenocarcinoma. I just wish I could find others that are at this same dosage as him, just seems so hard to find. Trying to determine if his side effects are more related to the treatment or the Whole Brain Radiation he had. I noticed this forum doesn't seem too active for the EGFR folks. Are you aware of other forums? Keep up the great work Warrior!

Hello I am a caregiver of my husband, diagnosed with NSCLC in 2021 Stage 1B. He had an upper lobectomy and recovered beautifully in 2022. He had clear chest scans all year. This past January he ended up in ER due to seizure which later revealed stage IV brain metastisis of multiple lesions (no cancer present in his lungs, thankfully). After resection of one of the tumors, EGFR Exon 19 deletion was confirmed lung cancer mets to the brain. He has since had WBRT and has began Tagrisso in February. He also has to take Keppra for seizure management. His dosage of Tagrisso is 120mg currently and they want him to the max of 160mg for full penetration to the brain. Does anyone here have experience on Tagrisso at this dosage? The combination of the whole brain radiation, keppra and tagrisso is challenging with side effects. Curious to see how many there are at this higher dosage as most I research people are at the 80mg dosage. Thank you in advance and much health to everyone!