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  1. Quick question: I was wondering if anyone had any experience to share with immuno or targeted therapy for SCLC. A few trials have shown efficacy of Keytruda and Opdivo in SCLC under certain circumstances. Previously, there hadn't been any signs of it working, so SCLC typically isn't even tested for genetic sequencing, protein expressions, etc. So, we're now in the process of getting the testing done for PDL1, TMB and genetic sequencing. Has anyone here taken Keytruda, Opdivo or anything else for SCLC? Any results to share? Experiences? Anything you can share would be very helpfu
  2. I was diagnosed in July 2013 at age 67 with NSCLC-adenocarcinoma, with mets to my liver. At the time, there were only a few mutations that were known; my testing revealed that I had none of them (ALF, EGFR, KRAS negative). I was started on chemotherapy - carboplatin, Avastin, and Alimta. After 16 months, a new tumor was detected and I was declared chemo-resistant. At that time, there were no FDA-approved immunotherapy treatments, so I was shown several clinical trials to review and discuss with my oncologist. The trial that we selected was a phase 1 combination of MEDI4736 (now known as durva
  3. Any thoughts/Experience?? High doses of vitamin C to improve cancer treatment passes human safety trial https://www.sciencedaily.com/releases/2017/03/170330142341.htm
  4. Hi. I just joined this site for help and support. My mother (age 70) was recently diagnosed with Stage IV NSCLC adenocarcinoma with mets to liver and bones. She is in poor health and has decided against chemo. She started the Opdivo and Yervoy combo today and we are all very anxious on what to expect and how she will respond. I would love to hear about any members' experiences with this immunotherapy combo! Thank you, and thank you for this forum.
  5. RonH

    Intro

    Joined this earlier this year and am just now trying to figure out how to post. I was diagnosed with Stage 3A NSCLC in June of 2018. Last year I completed 7 weeks of Concurrent Chemo-Radiation, then 5 weeks of Consolidation Chemotherapy and as of this week (July 29th, 2019) have now received 17 of 24 immunotherapy infusions of Durvalumab. I have my next CT scan and MRI in a few weeks and am hoping for the best.
  6. Anyone have experience dealing with stage 4 non small cell lung cancer, KRAS mutation and low PDL-1 expressor? My husband had surgery just over a year ago where a tumour was removed in lower and middle right lung. He now has 10+ micro nodules in his left lung. I realize this is a long shot. I’m new to this forum. thanks.
  7. Hi, my father had been dx with SCLC in January and underwent the cycles of carboplatin+ etoposide + tecentriq (immunotherapy) with fairly good response. Now his onco team are planning to do radiation (IGRT) along with carbo+ etoposide. They are saying adding tecentriq to the regime will be too toxic. Has anyone undergone/going through chemo+immunotherapy+ radiation simultaneously ? Prompt response would be of great help
  8. First off, I am a stage 3 NSCLC patient who was first diagnosed January of 2015. I underwent surgery (thoroscopic wedge resection) to remove a lime size tumor from my right lung. Everything seemed to be going good until a year later when a recurrence occurred in both lungs and the lymph nodes in my chest. More surgery was not an option so I was scheduled to begin radiation therapy and chemo. the radiation had some unpleasant side effects but resolved the issue with my lymph nodes. The chemo had very limited success so after a few months off to recover I started my second round of platinum base
  9. LUNGevity Foundation, the nation’s leading lung cancer-focused nonprofit organization, announced today the recipients of its 2018 Career Development Awards (CDA) for lung cancer research. These coveted awards fund critical lung cancer research projects and offer the recipients world-class mentorship by LUNGevity’s prestigious Scientific Advisory Board. “We are excited to support these exceptionally talented new investigators. Interestingly, all three of these projects involve liquid biopsy-based approaches to detecting and optimizing treatment of lung cancer. These new projects may defin
  10. Here is the weekly clip report: Cure “Lung Cancer Care Becoming More Personalized and Trials will Too” https://www.curetoday.com/articles/lung-cancer-care-becoming-more-personalized-and-trials-will-too Cancer Therapy Advisor “Lurbinectedin Receives FDA Orphan Drug Status for Recurrent Small-Cell Lung Cancer” https://www.cancertherapyadvisor.com/lung-cancer/lung-cancer-nsclc-lurbinecedin-fda-oprhan-drug-status-treatment/article/786009/ U.S. News – Health “What to Know about Lung Cancer Screening Guidelines” https://www.nga.org/governors/addresses/ Healio “Minimal
  11. Hello, this is my first post. My dad was diagnosed with Stage 4 lung cancer, non-small cell, adenocarcinoma the end of July. They found 10-13 lesions in the brain, one area on the adrenal gland , one on the spine , and possibly a small area on the liver. My dad had 2 weeks of radiation on the brain immediately. Before treatment, he got very unsteady and had a drop foot. After radiation, he got most of his coordination back. He had palliative radiation to the place on his spine for pain. Last Monday, my dad's oncologist put my dad on 2 chemo drugs (not sure the names at this time) and ketruda
  12. I've got a great update and a decision to make. After a resection of a small brain tumor plus gamma knife and just two cycles of chemotherapy, my Mom is presenting as NED (no evidence of disease) with small-cell lung cancer (SCLC). She has no side-effects from chemo, so she will go through 6 full cycles. However, I want to line up the next treatment. Usually, there is no maintenance regime with SCLC. We have 3 options: 1) Thoracic Radiation - Accepted to suppress the cancer from coming back, but may this preclude us from future clinical trials, many of which have prior radiation
  13. Here is the weekly clip report: U.S. News & World Report "From the 'Big C' to Cancer" https://health.usnews.com/health-care/patient-advice/articles/2018-03-21/from-the-big-c-to-cancer Healio “Lower-Limb Arterial Thrombosis May Be Marker of Cancer” https://www.healio.com/cardiac-vascular-intervention/peripheral/news/online/{f342b55f-87eb-4edc-a0eb-608633079467}/lower-limb-arterial-thrombosis-may-be-marker-of-cancer Medscape “How to Improve Diversification of Patients with Cancer in Clinical Trials” https://www.medscape.com/viewarticle/894210 Oncology Nursing Ne
  14. Here is the weekly clip report: WRC-TV “Exhibitors Guide: Full List of Exhibitors at the 2018 Health and Fitness Expo” https://www.nbcwashington.com/news/health/Exhibitors-Guide-Full-List-Exhibitors-Health-and-Fitness-Expo-474441813.html Immuno-Oncology News “Bristol-Myers, Nektar Developing Cancer Therapy to Be Used with Checkpoint Inhibitors” https://immuno-oncologynews.com/2018/02/26/bristol-myers-squibb-nektar-cancer-immunotherapy-checkpoint-inhibitors/ Color.com – Blog/Podcast “Adam Klein, Winner of 2016 Survivor, on Becoming a Leading Lung Cancer Advocate” https://b
  15. Co-written by LUNGevity and Mesothelioma Cancer Alliance A recent shift in cancer treatments from traditional, aggressive, overarching methods to targeted therapies tailored to individual patients and their medical situation has produced a resurgence of research in immunotherapy as a cancer treatment including multiple FDA approvals in the last few years. Today we are it taking a moment to reflect on how immunotherapy has progressed over the last twenty years. Immunotherapy is nothing new and has been in use for more than a century, but its potential is often seen as a mystery. While the
  16. Here is the weekly clip report: PR Newswire “LUNGevity Foundation Kicks Off New Public Service Campaign to Alter View of Lung Cancer Diagnosis” https://www.prnewswire.com/news-releases/lungevity-foundation-kicks-off-new-public-service-campaign-to-alter-view-of-lung-cancer-diagnosis-300583589.html Baylor College of Medicine “Immunotherapy Treatment Gives Lung Cancer Patient Second Chance” https://blogs.bcm.edu/2018/01/22/immunotherapy-treatment-gives-lung-cancer-patient-second-chance/ Variety “Allison Shearmur, ‘Rogue One,’ “Hunger Games’ Producer, Dies at 54” http://varie
  17. The treatment landscape of non-small cell lung cancer (NSCLC) is rapidly evolving, with the development of genetically targeted therapies and immunotherapy. Since 2015, the US Food and Drug Administration (FDA) has approved nine new drugs for the treatment of NSCLC, three reapprovals, and six new indications for an existing treatment. However, the side effects and toxicities of these treatments can be significant. With the emergence of new treatment options for lung cancer, the complexity of treatment decisions for people living with lung cancer has increased. With these treatment options
  18. Patients' Gray Hair Turns Dark After Immunotherapy for Lung Cancer A surprising side effect of lung cancer treatment is turning heads. BY MINDY WAIZER Cancer treatments can have some terrible side effects. But one recent immunotherapy treatment for lung cancer has turned up a surprising — and not unwelcome — result. The patients’ gray hair turned significantly darker. The study, which was published in JAMA Dermatology, examined 14 patients who have non-small cell lung cancer (NSCLC) and were receiving immunotherapy treatments including one of the following agents: Opdivo (ni
  19. Hi - I just got diagnosed two weeks ago with adenocarcinoma. I had been diagnosed with pneumonia for a couple of months until a follow up x-ray showed spreading in the lungs and a CT scan was ordered and a pulmonologist did a bronchoscopy. I had to insist on doing biopsies. I wanted to find out why my cough wasn't getting better and my chest hurt when breathing. So here we are, two weeks in. I've had a clear CT brain scan, waiting for PET scan results and molecular studies/pathology. I have seen the oncologist exactly one time not even a week ago. He told me that surgery isn't an option. It is
  20. Here is the weekly clip report: The ASCO Post “Stand Up To Cancer Launches ‘Cancer Interception’ Teams to Detect and Treat Cancer at Earliest Stages” http://www.ascopost.com/issues/november-25-2017/stand-up-to-cancer-launches-cancer-interception-teams-to-detect-and-treat-cancer-at-earliest-stages/ Stanford Medicine News Center “Stanford Scientists among Those Funded by Stand Up To Cancer” https://med.stanford.edu/news/all-news/2017/11/stanford-scientists-among-those-funded-by-stand-up-to-cancer.html Immuno-Oncology News “Imfinzi Increases Time for Non-Small Cell Lung Cance
  21. It’s an exciting time to be in cancer research and to watch some of these therapies move rapidly from clinic to improving the lives of patients. Sponsors play an important role during development by spearheading innovation, staying flexible, and planning accordingly for the rapid pace. Read more: http://medcitynews.com/2017/08/precision-medicine-immunotherapy-influencing-clinical-trial-design-cancer-drugs/
  22. http://gisborneherald.co.nz/localnews/2941654-135/call-for-keytruda-drug-for-lung WAITING FOR GOOD NEWS. Cancer patient Alain Jorion is hoping Keytruda will be funded for New Zealanders battling lung cancer. HIGH-profile Gisborne fisherman Alain Jorion is calling for the “wonder drug” Keytruda to be funded for lung cancer patients. “It is my one and only hope,’’ the cancer patient said. Last year Keytruda, after a much-publicised public campaign, was funded by Pharmac, but for people with advanced stage 4 and 5 melanoma only. Mr Jorion and other lung cancer patients a
  23. An updated ASCO clinical practice guideline clarifies the appropriate use of immunotherapy and provides new recommendations on the use of targeted therapy for patients with stage IV non-small cell lung cancer. https://www.healio.com/hematology-oncology/lung-cancer/news/in-the-journals/{e2dd9827-3259-4b42-9154-b7828218d5f5}/asco-updates-guideline-on-systemic-therapy-for-non-small-cell-lung-cancer
  24. https://conquer-magazine.com/recognizing-treating-immunotherapy-side-effects/?utm_source=bronto&utm_medium=email&utm_term=Recognizing+and+Treating+Immunotherapy+Side+Effects&utm_content=Weekly+News:+The+Voice+Within&utm_campaign=2017-08-09-Conquer+etoc IMMUNOTHERAPY, SIDE-EFFECTS MANAGEMENT - JUNE 21, 2017 Recognizing and Treating Immunotherapy Side Effects By Wayne Kuznar Enthusiasm for immunotherapy in the treatment of cancer must be balanced with a healthy consideration of the power of T-cell activation, which can cause the immune system to overact
  25. Hi. My mom was recently diagnosed with lung cancer, well, they did a biopsy and found cancer in her lung. we don't know yet the stage or origin. she is a long time smoker, but only 53. I am really hoping they found it early, even though I know that is rarely the case. My question today is she has an appointment set and it lists 3 different departments she is meeting with. Radiation/Oncology, Hematology/Oncology, and behavioral medicine. the radiation oncology is obvious , but can anyone tell me what roles the other 2 have in treatment of lung cancer ?
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