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Found 6 results

  1. My dad was recently diagnosed with Stage IV Metastatic Adenocarcinoma with cancer in his lungs, bone, and a tumor near his spine. He's currently getting radiation for that tumor. He is in his early 70s (although most people think he's much younger), he smoked in his teens for about 5-6 years, but quit in the 1970s. Six years ago, he had his right middle lobe removed because it was malignant. He hadn't had any symptoms since, we just recently learned about this. He has been tested and the results are negative for PD-L1, ALK, BRAF, and ROS1, but positive for the EGFR analysis (Exon 19 & T790M). He will be starting Tagrisso (osimertinib) as soon as the prescription is ready: 1. Is it worth inquiring about the KRAS test? 2. Is there anyone out there as old as he is? Has osimertinib been working for you? 3. Should we combine chemo with the osimertinib? 4. What has been your prognosis?
  2. Anyone have experience dealing with stage 4 non small cell lung cancer, KRAS mutation and low PDL-1 expressor? My husband had surgery just over a year ago where a tumour was removed in lower and middle right lung. He now has 10+ micro nodules in his left lung. I realize this is a long shot. I’m new to this forum. thanks.
  3. Here is the weekly clip report: Cure “Lung Cancer Care Becoming More Personalized and Trials will Too” https://www.curetoday.com/articles/lung-cancer-care-becoming-more-personalized-and-trials-will-too Cancer Therapy Advisor “Lurbinectedin Receives FDA Orphan Drug Status for Recurrent Small-Cell Lung Cancer” https://www.cancertherapyadvisor.com/lung-cancer/lung-cancer-nsclc-lurbinecedin-fda-oprhan-drug-status-treatment/article/786009/ U.S. News – Health “What to Know about Lung Cancer Screening Guidelines” https://www.nga.org/governors/addresses/ Healio “Minimally Invasive Surgery Effective for Early-Stage Lung Cancer” https://www.healio.com/hematology-oncology/lung-cancer/news/in-the-journals/{924a7fc0-fcda-4ffb-bad7-4f2cb101c1db}/minimally-invasive-surgery-effective-for-early-stage-lung-cancer Onc Live “Dr. Witsuba on Biomarkers for Immunotherapy in Lung Cancer” https://www.onclive.com/onclive-tv/dr-wistuba-on-biomarkers-for-immunotherapy-in-lung-cancer Drug Target Review “Reducing NOVA1 Helps prevents Tumour Growth in Lung Cancer” https://www.drugtargetreview.com/news/34089/reducing-nova1-lung-cancer/ Science Daily “Finally, a Potential New Approach against KRAS-Driven Lung Cancer” https://www.sciencedaily.com/releases/2018/08/180809093458.htm Oncology Nurse Advisor “New PDL1 Inhibitors for Non-small Cell Lung Cancer: Focus on Pembrolizumab” https://www.oncologynurseadvisor.com/lung-cancer/pdl1-inhibitors-for-nsclc-focus-on-pembrolizumab/article/787627/
  4. HI All, To be honest, I'm not sure exactly what I"m doing here or what I'm seeking from this site other than a bit of comfort and maybe to read others stories and share in the community of people who are also walking similar/the same path. Maybe someone to validate my feelings occasionally as I oscillate between sadness, happiness, intense anger, sentimentality and all the feelings in between. I come from a long history of cancers (not all lung) on my Mom's side of the family. My Mom is one of eight and of those eight two are living (my Mom and her brother). Of those that have passed, 4 out of 6 have died from cancer. The oldest of her siblings was only 73. Out of the 4, 3 of them didn't make it out of 6 months post diagnosis and only one made it to treatmand ent. My Mom started smoking when she was 11 years old. When she was diagnosed with COPD in 2010, I begged her to quit and stop/slow the progression as much as possible. I, too, was a smoker at the time and we had already lost my two of my uncles to cancer. I didn't want her to get sick. As a measure of solidarity, I quit smoking on her birthday that year and I've now been smoke free for 7 years, except for two single cigarettes over the course of that time. I'd been predicting my Mom's future for years but could not get her to quit smoking. On December 8, 2016 I was in the UK traveling on business. My Mom, who's family nickname is Tuffy, had been struggling with what she thought was pneumonia for a while. Getting her to go to the doctor at the time was no small feat of will and she kept telling us all she was fine even though she was having pain. The pain got severe enough in her chest/shoulder/arm that she thought she might be having a heart attack (although possibly the longest heart attack on record) and went to the doctor while I was away. She called me while I was away to tell me she was going. She then called me later to tell me she did have pneumonia, but they found a mass in her lung and that they were going to send her for a biopsy. I was a wreck. I was nearly 3,500 miles away and felt totally helpless and deep in the pit of my stomach I knew what the news would be. I can remember calling my last surviving uncle that night (after having more wines than I should with colleagues at a couple of pubs) and just sobbing that I didn't want to lose my Mom and I didn't know how I was going to be strong enough to go through this with her. I completely came unraveled. My Mom had the biopsy and I traveled back a few short days later on December 10, 2016. On December 15, 2016 her pulmonologist confirms that it is in fact cancer. Adenocarcinoma NSC. He wants her to come back for a test to determine her lung capacity and sends her to a top thoracic in the area. The lung capacity test shows that she's not a good candidate for surgery. She also can't have surgery because she is still smoking and they are concerned the cancer has spread to the chest wall and its in a lymph node near her heart. He refers her to see an oncologist for treatment options. We have a great one local we know from another family members cancer journey and get an appointment with her. Fast forward to our appointment with the oncologist in mid January. She stages my Mom at about a Stage II MAYBE Stage III. The oncologist is ready to start her for treatment in the coming weeks and sends her for a precautionary brain scan since the PET scan doesn't cover this. The scan was done on January 23rd. On January 24th, I received a phone call that they found something in my Mom's brain and we needed to go immediately to the neurosurgeon for evaluation. The news is promising in that it's one tumor and a candidate for surgery. My Mom is admitted to the ER that night and has brain surgery the next morning. She does fantastic. All her doctors can't get over how well she did and how she didn't show any symptoms of the tumor prior to the scan. Immediately, my Mom is now a Stage IV lung cancer patient. After recovering for a bit, she starts chemo and radiation. Chemo is carboplatin and pemetrexed. The Neulasta makes my Mom violently ill so they have to switch her to neupogen so she can sustain treatment. During this, Mom goes through genetic testing to determine the mutations she displays. None of them are available for targeted therapies. At this point though, I don't know what genetic mutation she has. She also goes in for a Cyberknife treatment on the area treated on her brain. Mom finished chemo on June 8th. She went for her follow-up PET scan on July 15th. On July 19th we are informed that Mom is in remission. No active cancer, all post treatment disease. We are elated and I book our trip to Florida that I promised I would take her on once she finished treatment and beat this (my mom from the start said she wouldn't let her take her down. She was fighting - and she did. Not once did she complain or look for sympathy. She just did everything with such grace and strength I could be nothing but amazed. I was pretty convinced if it were me I'd be in a pile on the floor somewhere). We went on that trip the first week of October of this year and it made some of the best and happiest memories I have with my Mom in my adult life. We had the most fun we've had in a long time. We even went to Disney and met Mickey Mouse (something I hadn't done in my childhood). She's still smoking. She's also had 2 follow-up brain scans since surgery and Cyberknife and everything looks great (side note: her neurosurgeon is probably the best doctor aside from her oncologist I've ever encountered in my life. I literally could just hug this man every time I see him) Towards the end of the trip and when we got back, she started to feel sick. She kept saying it was just a cold. By mid October, pain had returned. She went to her PCP, who said she just had a respiratory infection and put her on antibiotics. The antibiotics don't help. At her follow up with her oncologist to get the appointment for her next PET Scan, the oncologist orders an Xray. The results come back that it looks like pneumonia in the lung. She follows up again with her PCP who gets another Xray and then tells her that its just bronchitis and puts her on Levaquan. She has a massive negative reaction, calls the oncologist who then prescribes Doxycycline. She does much better on that but the pain isn't going away. According to her PCP, there's nothing in her lung except the bronchitis. She went in for her PET scan on Saturday, November 18th. We got the results on Monday and it shows that her cancer has returned. Two masses in her left lung along with multiple nodules in both. Thankfully it's spread nowhere else. We met with the oncologist yesterday who wants Mom to go through a second line treatment of chemotherapy with Carboplatin, Abraxane and Avastin. 3 weeks on, 1 week off for 3 months. She said her third line treatment would be some sort of immunotherapy although they are not sure how effect it will be since she doesn't have PDL-1. I did find out during this appointment that her genetic mutation is KRAS. The "mama bear" daughter in me who wants to know everything (boy am I naive) and has an eternal thirst for knowledge made the mistake of looking it up last night around 11 pm EST. Needless to say I didn't sleep very well. I need to take my own advice as I always tell people "Google is not your friend". My Mom has said she is finally going to quit smoking but I don't have much faith. Not that at this point it's going to stop anything but it certainly isn't going to hurt. I'm a whole whirlwind of emotions - I'm mad at her that she is putting smoking before her family and her health, I'm sad that she has to fight again. I'm proud of her for fighting as hard as she had and not flinching when they told her she'd have to go back through treatment. I'm worried for the future. My sister lives with her with her two kids and significant other as well as my Dad. I'm single still with no children and that weighs heavily on my mind as well. I constantly battle with myself feeling like I should be doing more. There's a part of me that wants to find some way to volunteer at a local cancer center or organize a charity event for cancer research. I spend time wanting to scream and wanting to just literally never be away from my Mom for another minute while she's here. This seemed like a safe place to explore and look for support from people who are going through the same thing. I'm sorry for the lengthy post. Things are still very raw for me. I look forward to being a part of the community here. Maigan
  5. SU2C Lung Cancer Dream Team Launches Website for KRAS-positive Lung Cancer Patients LUNGevity President Andrea Ferris presents new site at SU2C Scientific Summit FOR IMMEDIATE RELEASE Media Contact: Aliza Bran [email protected] (202) 414-0798 WASHINGTON, January 29, 2016 - LUNGevity President Andrea Ferris, a member of the Stand Up to Cancer Lung Cancer Dream Team, presented the team’s newly launched website, a patient-centric resource that enables users to be active, informed participants in their diagnosis and treatment, at a poster session at the 2016 Stand Up to Cancer (SU2C) Scientific Summit. Ferris is an advocacy representative on the Lung Cancer Dream Team, created in April 2015 to address treatment options for patients with KRAS-mutant lung cancer. She helped create the patient-friendly website and guided its December launch. The resource will help patients understand their disease and treatment options, report on the Lung Cancer Dream Team’s research progress, and inform patients of open clinical trials. “This patient population has never seen significant progress,” noted Ferris. “Our goal in creating this website was to provide hope to people diagnosed with KRAS-mutant lung cancer. We designed the site with the patient in mind, so that they can be informed participants in their health care decisions.” “While there have been meaningful steps forward in lung cancer research, treatments for patients with the KRAS mutation have seen little success,” said Jeffrey Engelman, MD, PhD, member of the Lung Cancer Dream Team’s Scientific Research team. “To be successful, it’s crucial that our team connect the science to the patient, and connect the patient to the science through enrollment in clinical trials. We can’t accomplish these goals without advocates who ensure that the patient voice and needs are incorporated.” To learn more about the SU2C Lung Cancer Dream Team and its work in KRAS-mutant lung cancer, visit www.lungcancerdreamteam.org. For more information on LUNGevity Foundation, please visit www.LUNGevity.org. About Lung Cancer 1 in 15 Americans will be diagnosed with lung cancer in their lifetime More than 221,000 people in the U.S. will be diagnosed with lung cancer this year About 60%-65% of all new lung cancer diagnoses are among people who have never smoked or are former smokers Lung cancer takes more lives than the next three leading cancers (colorectal, breast, and prostate) combined Only 17% of all people diagnosed with lung cancer will survive 5 years or more, BUT if it’s caught before it spreads, the chance for 5-year survival improves dramatically http://www.lungevity.org/about-us/media-resources/news-from-foundation/su2c-lung-cancer-dream-team-launches-website-for-kras
  6. My mother was diagnosed about 2 years ago with Stage IIIb / IV NSCLC (one site w/pleural effusion). The tumor is inoperable due to location (and no radiation option either). She tested positive for the EGFR mutation and has been on Tarceva (after chemo - Alimta, Carboplatin, Avastin) for just over one year. Now the cancer is growing, and they tested for the T790 mutation, likely to be present once resistance to Tarceva shows. However, not only did they find the EGFR and T790 mutations, but they now see the KRAS mutation, which is highly unusual. The KRAS and EGFR are considered to be mutually exclusive. I'm interested to know if anyone has encountered this? We're getting her into a study for the T790, but not certain about options to address the KRAS mutation.
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