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Looking for input on Opdivo/Yervoy treatment for locally recurring SCLC or success in repeating 1st line chemo/radiation. Apologies for message length. I have been diagnosed with a local recurrence of small cell lung cancer. I was originally diagnosed with Limited Stage SCLC Oct 31 2017, had a full response to treatment (Carboplatin etoposide with concurrent Radiation) which ended January 17 2018. So it’s been about a year. My oncology team is recommending I go straight to immune therapy (Opdivo & Yervoy) I’m struggling with do I go forward with immune therapy (Opdivo and Yervoy) or given local recurrence ( ie no distant Mets ) do I push to repeat prior chemo/radiation treatment . Would want to possibly redo radiation (which may be possible) Would be interested in anyone opinion on this, experience with treatment with Opdivo/Yervoy. Also if anyone has had success with repeating original chemo/radiation treatment. The local recurrence is in right bronchus intermedius. Subcarinal lymph node 1.3 cm, 5.2 FDG update and azygos esophageal recess (1.64 cm with 4.6 FDG uptake) . Again no Mets elsewhere. Having an MRI (brain) this week.
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My husband started immunotherapy treatment for metastatic cancer on October 15th, which spread from kidney cancer. It is renal cell carcinoma and he has several small tumors in each lung and one affecting a lymph node by his adrenal gland...which is near where his affected kidney was before it was removed. He didn't get to start treatment right away, because doctors wanted his kidney out first and he needed to heal before starting the immunotherapy. My husband had his first CT scan on December 13th, but it showed about 30% growth of all of the tumors. They told him it could be because the tumors grew that much or more between his diagnosis in late August until his treatment began, which was 6 1/2 weeks later. His oncologist said that many patients don't see their tumors shrink until four months after treatment starts. We would just like to know if anyone has been on immunotherapy (possibly both Yervoy & Opdivo) and had to wait four months to see their tumors start to shrink.