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Large and small cell carcinoma


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I am posting this for a dear family friend. Her husband was just diagnosed with both large and small cell carcinoma, mets to brain and liver. They were told this large and small cell combination is particularly difficult to treat.

Is it common to have this combination and what about it makes it harder to treat than small or large cell alone?

Thank you!

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Depends, there is a large cell neuroendocrine cancer (sometimes called large small cell cancer, I know that makes no sense at all....) and large cell cancer which is basically a variant of adenocarcinoma. Neither is particularly rare. If she has the NSCLC version of large cell, it complicates things because the treatment for small cell and NSCLC are different. The rule of thumb is that you treat the more aggressive histology (small cell).

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