Bill Posted May 29, 2005 Share Posted May 29, 2005 My wife's pharmacist refilled her Tarceva and stored it in the refrigerator ( in the original, manufacturer's foil sealed container ). Looks like it was in the fridge for ~ 24 hours before I picked it up. Refrigerator temperature would be below the manufacturer's recommended storage temperature range. Because the container is sealed I'm not really concerned about moisture damage but I'm concerned about cold storage stability generally. I can't locate any cold storage stability info on Tarceva ( or Iressa ). The manufacturers don't have any specific knowledge about this subject, either. Just guessing. Actually, there is very little, if any, cold storage data available on any non-refrigerated pharmaceuticals. Studies deal primarily with freezing and high temps. Does anybody have any experience with refrigerated Tarceva ( or Iressa ) ? Thanks. Quote Link to comment Share on other sites More sharing options...
Ry Posted May 30, 2005 Share Posted May 30, 2005 I know Iressa had an 800 number for questions so maybe Tarcava does too. You could google it and see. Quote Link to comment Share on other sites More sharing options...
Justakid Posted May 30, 2005 Share Posted May 30, 2005 www.tarceva.com may help also. If nothing else you could email them your question! Quote Link to comment Share on other sites More sharing options...
Jana_W Posted May 30, 2005 Share Posted May 30, 2005 If the recommended storage condition states a specific temperature range, and you know it was stored outside this range then I would ask for a new batch that comply with the storage conditions. Is this possible? Usually when companies conduct "storage condition" testing they do test the product at a range of different temperatures, so you may be able to obtain this information but only if the tests were done at that temperature. Cheers Jana xx Quote Link to comment Share on other sites More sharing options...
Bill Posted May 30, 2005 Author Share Posted May 30, 2005 Thanks for the suggestions but I've already contacted the various manufacturers and I even made my inquiries as a " healthcare professional " ( which I am ) in an attempt to get a better response. No luck. These people can tell you alot about marketing but nothing about cold storage. Just educated guesses that it's no big deal. I've even exhausted all of my professional contacts and reference sources. Nothing. Just thought I'd take a shot at asking the board if someone taking Tarceva ( or Iressa ) had personally dealt with this issue. Probably nothing to worry about but I'm too close to the situation to brush it off so quickly w/o digging deeper. BTW, since we are on the topic of drug storage, and many cancer-related pharmaceuticals must be kept refrigerated, base on my experience just about the # 1 drug error that I've seen in the clinical setting over the years is failure to refrigerate pharmaceuticals that require refrigeration. This is a major problem that is, unfortunately, easily covered up once discovered. Sometimes to the patient's detriment. So, be vigilante. Quote Link to comment Share on other sites More sharing options...
Jana_W Posted May 30, 2005 Share Posted May 30, 2005 Are you able to obtain another packet of tablets, that has been stored appropriately? Quote Link to comment Share on other sites More sharing options...
j ross Posted May 30, 2005 Share Posted May 30, 2005 My husband worked as senior researcher for a very large drug co. He tells me that storing tarceva in a fridge would not deminish its efficacy. Jenni Quote Link to comment Share on other sites More sharing options...
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