Bill Posted December 1, 2005 Share Posted December 1, 2005 My wife is NED but has developed diffuse postradiation ( WBR ) leukoencephalopathy. No point in second guessing WBR vs. alternative tx options. This is just a friendly warning to you that postradiation leukoencephalopathy is a delayed onset adverse effect of WBR ( as well as focal brain tx ). It can happen with or w/o chemo ( some studies blame rad + chemo ) and the incidence is very high. Upwards of 80% in patients in their 50's. A real sleeper that suddenly pops up with symptoms ( confirmed by brain MRI ) usually ~ 6 months to 2 years after WBR or focal brain tx. The symptoms can be numerous, progressive and devastating. Basically proportional to the amount of brain irradiated. Many patients, including my wife, aren't warned of this risk, or at least the magnitude, at the time of tx. Like I said, I'm not second-guessing the decision to use WBR in my wife's case. There are apparently some less destructive tx options to WBR but discussing the qualifying tx criteria for these alternatives is beyond my knowledge and the scope of this post. My wife's usually very accessible rad onc has suddenly become " unavailable " for comment. Good luck. Quote Link to comment Share on other sites More sharing options...
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