john Posted September 3, 2003 Share Posted September 3, 2003 In recent phase III randomized trials of lung cancer patients treated with chemoradiation therapy, amifostine(Ethyol) significantly reduced acute pneumonitis from 23% to 3.7% (P = .037), without any reduction in tumoricidal activity. http://dukemednews.duke.edu/global/download.pdf?ids=89 Pentoxifylline with vitamin E has recently been shown to cause regression of RT-induced fibrosis. http://www.cancernetwork.com/handbook/pdf/46radtox.pdf http://essiac-info.org/BobK/article1.html http://www.lef.org/protocols/prtcl-025a.shtml Quote Link to comment Share on other sites More sharing options...
Jenny G. Posted September 4, 2003 Share Posted September 4, 2003 Hi John, The radiology nurse told me to buy stock in the company that makes Amifostine, maybe I should have listened. Jenny Quote Link to comment Share on other sites More sharing options...
Sam'swifeShirley Posted September 4, 2003 Share Posted September 4, 2003 Boy do I wish I'd known this before I had my chest radiation last year. Who knows how much better off i might be now. I think that anyone now undergoing concurrent chest radiation and chemo should probably get Amifostine. Sam Quote Link to comment Share on other sites More sharing options...
beckyg Posted September 4, 2003 Share Posted September 4, 2003 Amen. At the moment I think radiation did me more harm than good, since my disease progressed during that stage and my breathing is significantly worse than before radiation thanks to the pneumonitis. Quote Link to comment Share on other sites More sharing options...
mhutch1366 Posted September 15, 2003 Share Posted September 15, 2003 I had exquisite ear pain from the cisplatin and vp-16 on the first round of chemo, and my oncologist recommended ethyol (amifosdine) to protect my ears/hearing, as it was originally designated to provide some protection to the kidneys during chemo. I had a wonderful experience with ethyol, my hearing loss was minimized (hearing loss is a sizeable risk with cisplatin, I am told), the ear pain was reduced and eventually subsided to mere chronic tinnitis. From what I am reading here, the protective effects are not restricted to kidneys and ears. If I hadn't asked the oncologist, I don't know he would have thought to offer me the option. ASK QUESTIONS!!! Be proactive in your own treatment. You are a partner in your treatments, a part of the team. I believe that ethyol prevented me from having to wear a hearing aid after recovery. Ask your oncologist. Ask, Ask, Ask. MaryAnn Thankful to be here. Quote Link to comment Share on other sites More sharing options...
Jenny G. Posted September 15, 2003 Share Posted September 15, 2003 More on Ethyol (Amifostine) from another thread on this board: http://www.buy2k.net/lungcancersurvivor ... ght=ethyol Quote Link to comment Share on other sites More sharing options...
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