Shelley (MLC) Posted April 14, 2007 Share Posted April 14, 2007 Hi everyone. I have been looking into 2nd line treatment options for my mom. She is currently only in the middle of 1st line treatment, and is doing very well, but I like to be prepared. I read everyone's history at the bottom of their posts, but not everyone with NSCLC includes whether they have squamous, adeno, etc. I believe that certain chemo agents cannot be used in squamous cell (ie avastin), so I'm looking for people here that have squamous cell. I know that I am looking into this a little early and hopefully, she won't need 2nd line for awhile, but I'd like to know what options are out there so that when the Dr presents us with his opinion, I'll have a little knowledge base. As always, thanks so much! Shelley Quote Link to comment Share on other sites More sharing options...
RandyW Posted April 15, 2007 Share Posted April 15, 2007 Ya got My researcher side going right now so here goes, Vinorelbine; http://www.ncbi.nlm.nih.gov/entrez/quer ... xed=google Cisplatin; http://www.future-drugs.com/doi/abs/10. ... 40.7.3.331 Etoposide Cisplatin combo; http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract Thats all I can locate for now but hope it helps somewhat. Quote Link to comment Share on other sites More sharing options...
wiesia Posted April 15, 2007 Share Posted April 15, 2007 I did some research on that for my father. In his case we did not know the type of NSCLC he had. The original bronchoscopy did not check that and later our doctor did not consider it necessary to check. I asked about and he said that in Europe squamous cell is more common but even with it they use Avastin unless the cancer is centrally located and ulcerated (bleeding) or there are brain mets. As for the usual types of chemo: I think there is practically no research on the activity in different types although recently there are some noises coming about treatments of BAC. Quote Link to comment Share on other sites More sharing options...
asmakis Posted April 15, 2007 Share Posted April 15, 2007 My dad had squamous cell. He too responded very well to the first line of treatment, but unfortunately after that, his response was not what the doctors had hoped. He was given 6 months to a year, and he made it just over 13 months. My dad's bio below shoud do a pretty good job with indicating which chemo's he took, but if you need to know anything else, please don't hesitate to ask. :)Amanda Quote Link to comment Share on other sites More sharing options...
Jyoung20 Posted April 15, 2007 Share Posted April 15, 2007 Is Tarceva an option? Quote Link to comment Share on other sites More sharing options...
Shelley (MLC) Posted April 15, 2007 Author Share Posted April 15, 2007 Thanks to all for your responses so far. Please keep them coming! Randy, I appreciate you putting on your research hat for me. I'll look into the links you sent. Jamie, I believe that Tarceva WILL be an option and I hope that it works as well as it has on many others here. I was not sure if the Dr. would be recommending another chemo combo BEFORE suggesting Tarceva. Such a learning curve here! Shelley Quote Link to comment Share on other sites More sharing options...
RandyW Posted April 15, 2007 Share Posted April 15, 2007 http://clinicaltrials.gov/ct/gui/show/N ... B?order=49 This is a link for a tarceva Clinical trial for Squamous Cell Carcinoma that is currently recruiting patients!! Quote Link to comment Share on other sites More sharing options...
rvillella Posted April 15, 2007 Share Posted April 15, 2007 Both of mine were squamous cell but they treated both as stage 1. Ralph Quote Link to comment Share on other sites More sharing options...
masspa Posted April 16, 2007 Share Posted April 16, 2007 Shelly, I don't have much info on second line treatments, 'cause Mom is still on her first treatment regimen. She has squamous cell stage III. because of her advanced age. she was going to have just chemo, but her radiation oncologist recommended both. Originally she was gonna have carbo/taxol, but she had a reaction to the taxol. there was then talk of Gemzar/carbo, but when the radiation decision was made, they went with carbe/etopside. That seemed to work very well for her. everything has shrunk considerably, and her most recent pet shows NED. THey're thinkng about surgery to remove whatever remains potential vibrant in the tumor, but the jury's still out on that one. Feel free to email any time if you need more info. Jen Quote Link to comment Share on other sites More sharing options...
dtay Posted April 16, 2007 Share Posted April 16, 2007 My Dad is stage 4 Squamous cell and his first line chemo failed - he is now on Tarceva. Dawn Quote Link to comment Share on other sites More sharing options...
moorech3 Posted April 16, 2007 Share Posted April 16, 2007 My mom's second line treatment was Alimta. Unfortunately it did not work for her, though it must work for some if he recommended it. All the best to you and your mom and I'll pray for you both. Quote Link to comment Share on other sites More sharing options...
Shelley (MLC) Posted April 16, 2007 Author Share Posted April 16, 2007 Thanks again everyone! I'm happy to have some background info on 2nd line and other chemo options for mom. I'm so proud of her. She is doing so well with her treatment and as always, her only concerns are about how well everyone around her is doing. Shelley Quote Link to comment Share on other sites More sharing options...
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