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Blood Type and Lung Cancer Risk


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Blood type and lung cancer risk

Source: (cancerfacts.com)

Wednesday, June 27, 2007

COPENHAGEN – June 27, 2007– Certain blood types appear to boost the risk of tobacco-linked lung cancer according to a new study.

Led by Dr. Poul Suadicani of the Bispebjerg University Hospital, Copenhagen, Denmark researchers found that among men with blood type A only smoking was linked to lung cancer deaths. Among men with blood type O, other risk factors in addition to smoking were linked to lung cancer deaths.

Tobacco smoking is the uncontested number one risk factor for lung cancer in men. Despite this, not all smokers develop lung cancer. There may be several reasons for this, including genetics and lifestyle factors other than smoking. In addition to smoking, occupational exposure to inorganic dust and asbestos, dietary factors and alcohol intake have been linked to risk of lung cancer.

Previous studies suggest that the role of risk factors may depend on a person's ABO blood group. To investigate whether risk factors were more or less important for different ABO blood groups, Suadicani's team conducted a study including more than 3,000 Copenhagen males aged 53 to 73 years. They were followed for 16 years. Blood group O and blood group A were equally frequent and comprised approximately 85% of the men. The researchers then compared lung cancer incidence and death among men with these two types of blood. The results of the study appear in the July 2007 issue of the European Respiratory Journal.

Among men with blood group A, only smoking was identified as a major risk factor for lung cancer mortality. Among men with blood group O, although only one of 84 men who died due to lung cancer had never smoked in this group, several other factors were statistically significantly associated with lung cancer mortality: a self-reported high salt intake; high fat intake; long-term occupational exposure to dust; and high alcohol intake.

SOURCE: European Respiratory Journal ABO phenotypes and inflammation-related predictors of lung cancer mortality: the Copenhagen Male Study - a 16-yr follow-up, July 1, 2007; online publication Mar. 2007

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