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Standard of Care for Small Cell Lung Cancer Remains/Combo

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http://patient.cancerconsultants.com/Ca ... nt,VePesid®,Platinol®,Small%20Cell%20Lung%20Cancer,extensive-stage,etoposide,cisplatin


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For patients diagnosed with extensive-stage small-cell lung cancer (SCLC), the standard-of-care remains the chemotherapy combination of VePesid® (etoposide) and Platinol® (cisplatin). A recent study indicates that Camptosar® (irinotecan) plus Platinol does not improve survival in SCLC compared with VePesid/Platinol. These findings were presented at the 2008 annual meeting of the American Society of Clinical Oncology.

Small cell lung cancer (SCLC) accounts for approximately 25% of all cases of lung cancer in the United States. SCLC refers to the type of cell within the lung from which the cancer originated. It is considered a very aggressive form of lung cancer.

Extensive-stage SCLC refers to cancer that has spread from the lung to different sites in the body. Approximately two-thirds of patients diagnosed with SCLC have extensive-stage SCLC; a standard chemotherapy regimen for these patients is VePesid plus Paraplatin. However, due to suboptimal long-term outcomes for patients with SCLC, researchers continue to evaluate alternative chemotherapy combinations to standard therapy.

In 2002 a trial conducted by Japanese researchers reported that Camptosar/Platinol produced a significant improvement in survival over the standard VePesid/Platinol for extensive-stage SCLC. In light of these results, researchers with the Southwest Oncology Group (SWOG) conducted a trial to validate these findings among patients in North America.

The SWOG trial included 671 patients with extensive SCLC. Participants were divided into two groups; one group received Camptosar in addition to Platinol, while the other group received VePesid in addition to Platinol.

Median progression-free survival was similar between both groups: approximately six months for patients treated with Camptosar compared with approximately five months for those treated with VePesid.

Median overall survival was also not significantly different between the two groups: approximately ten months for the Camptosar group and approximately nine months for the VePesid group.

The researchers concluded that in North America, VePesid/Platinol remains the standard of care for patients diagnosed with extensive-stage SCLC. Patients undergoing treatment for SCLC may wish to discuss with their physician the risks and benefits of treatment with a combination of VePesid and Platinol.

Reference: Natale, R et al. S0124: A randomized phase III trial comparing irinotecan/cisplatin (IP) with etoposide/cisplatin (EP) in patients (pts) with previously untreated extensive stage small cell lung cancer (E-SCLC). Proceedings from the 2008 annual meeting of the American Society of Clinical Oncology (ASCO). Abstract 7512.

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(Cancer Consultants, Oncology Resource Center, June 7, 2008)


The information contained in these articles may or may not be in agreement with my own opinions. They are not posted as medical advice of any kind.

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