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Survey and Blood Sample Collection for Patients with Lung Cancer Who Never Smoked Cigarettes

http://www.mskcc.org/mskcc/html/2270.cfm?IRBNO=08-104

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Survey and Blood Sample Collection for Patients with Lung Cancer Who Never Smoked Cigarettes

[Protocol 08-104]

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Full Title :

SURVEY AND BLOOD SAMPLE COLLECTION FOR PATIENTS WITH LUNG CANCER WHO NEVER SMOKED CIGARETTES

Purpose :

Lung cancer is the leading cause of cancer-related death in the US and worldwide. Most patients who develop lung cancer have a history of smoking cigarettes. However, about 1 in 10 lung cancer patients has no history of direct tobacco exposure. A majority of these patients are women and have a subtype of lung cancer with adenocarcinoma histology. It is believed that that these "never smokers" may have genes that predispose them to lung cancer. No such genes have yet been identified.

The purpose of this study is to determine if collecting information and blood from a group of people who never smoked but who have lung cancer is possible across the US.

Researchers will collect information on each patient's diagnosis and treatments. If the collection is successful, blood samples will be used for so-called "whole genome association studies" to look for differences between the genomes of never smokers with and without lung cancer. This may help to identify new genes, which may explain and predict why certain patients develop lung cancer without having smoked tobacco. This is the first step to establish strategies to prevent lung cancer or find people who are at high risk for this disease.

Eligibility :

To be eligible for this study, patients must meet several criteria, including but not limited to the following:

being above age 18

having non-small cell lung cancer

being a never smoker, defined as having smoked less than 100 cigarettes over the entire lifetime.

Participation in our research study involves filling out a short questionnaire and giving a blood sample. Participants can have these tubes of blood drawn when they have routine blood tests performed at a doctor's office or at a local laboratory testing provider. There are no costs involved to participate in this study.

For more information and to see if you are eligible for this study, please use our online form. If you would prefer to speak with someone, please contact Dr. William Pao, Principal Investigator, at 1-866-854-4652. You can also contact us by e-mail at neversmokerswithlungcancer@mskcc.org.

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