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Findings Provide New Insights Into Non-Small-Cell Lung Carci


KatieB

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Findings From University Of Texas M.D. Anderson Cancer Center, M.D. Anderson Cancer Center Provide New Insights Into Non-Small-Cell Lung Carcinoma

Scientists discuss in 'Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions' new findings in non-small-cell lung carcinoma. In this recent study, researchers in the United States conducted a study "To identify the pattern of interleukin-1 receptor-associated kinase (IRAK-1) protein expression in non-small cell lung carcinoma (NSCLC) and corresponding preneoplastic lesions. Archived tissue from NSCLC (adenocarcinoma and squamous cell carcinoma; n06) and adjacent bronchial epithelial specimens (n15) were analyzed for the immunohistochemical expression of IRAK-1, and the findings were correlated with patients' clinicopathologic features."

"Furthermore, we investigated the correlation between IRAK-1 expression and expression of NF-kappaB and IL-1alpha in tumor specimens. NSCLC tumors showed significantly higher cytoplasmic and lower nuclear IRAK-1 expression than normal epithelium. Squamous dysplasias had significantly higher cytoplasmic IRAK-1 expression than normal epithelium. In tumors, a significant positive correlation was detected between IRAK-1 expression (nuclear and cytoplasmic; p=0.011) and IL-1alpha cytoplasmic expression (p Non-Small-Cell Lung Carcinoma).

The researchers concluded: "IRAK-1 is a novel inflammation-related marker and a potential target for lung cancer chemopreventive strategies."

Behrens and colleagues published their study in Clinical Cancer Research (Expression of interleukin-1 receptor-associated kinase-1 in non-small cell lung carcinoma and preneoplastic lesions. Clinical Cancer Research, 2010;16(1):34-44).

For more information, contact C. Behrens, The University of Texas MD Anderson Cancer Center, Departmentsof Thoracic, Head and Neck Medical Oncology, Houston, Texas 77030-4009 USA.

Publisher contact information for the journal Clinical Cancer Research is: American Association Cancer Research, 615 Chestnut St., 17TH Floor, Philadelphia, PA 19106-4404, USA.

http://www.cancercompass.com/cancer-new ... /32897.htm

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