Cary Posted January 31, 2004 Share Posted January 31, 2004 This research indicates that maitake actually increases VEGF, which would be a negative thing for cancer patients. I don't know if the immune response outweighs the risk for increased angiogenesis/migration(mets)though. Cary Cancer Lett. 2001 Oct 30;172(2):193-8 Effects of maitake (Grifola frondosa) D-Fraction on the carcinoma angiogenesis. Matsui K, Kodama N, Nanba H. Department of Microbial chemistry, Kobe Pharmaceutical University, 19- 1, Motoyama-kitamachi 4-chome, Higashinada-ku, 658-8558, Kobe, Japan. We have reported that D-Fraction extracted from maitake (Grifola frondosa), activates immune competent cells, and indicates anti-tumor activities. The D-Fraction was observed to induce angiogenesis in vivo and to enhance the proliferation capability and migration capability of human vascular endothelial cell in vitro. The D- Fraction also increased plasma vascular endothelial growth factor (VEGF) concentration significantly. Also VEGF and TNF-alpha production by the activated peritoneal macrophages were enhanced. These results suggest that the anti-tumor activity of the D-Fraction is not only associated with the activation of the immuno-competent cells but also possibly related to the carcinoma angiogenesis induction. PMID: 11566496 Quote Link to comment Share on other sites More sharing options...
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