Rower Michelle Posted June 25, 2019 Share Posted June 25, 2019 I’m willing to sell tickets to that show down tomorrow! Anyway, I’m looking at the June 2019 American Society of Oncology Association. (ASCO) abstracts. It appears as if your medical team is humming along with the new chemo immunotherapy protocol. Typically administered when there is no PDL-1 or targeted mutation. Early studies suggest good results in PFS. Ask the doc to show you which abstract is most applicable and have them provide you with a copy. Sounds like this is going to be worth it in the long run. Good luck-lock and load. Eagle13, Tomm, Kleo and 1 other 4 Link to comment Share on other sites More sharing options...
Kleo Posted June 25, 2019 Share Posted June 25, 2019 Yes Rower Michelle!.... This is the new protocol now....just as the durva was. Gotta wonder..... how similar are Tecentriq and durvalumab considering they target the same thing? Just like Keytruda and durvalumab….🤔 Charles, Eagle13, Rower Michelle and 1 other 4 Link to comment Share on other sites More sharing options...
Robert Macaulay Posted June 25, 2019 Author Share Posted June 25, 2019 Kleo If this makes sense please let me know😎 Atezolizumab (Tecentriq®) Atezolizumab (Tecentriq, Genentech USA, Inc, San Francisco, CA, USA) is a monoclonal antibody that binds to PD-L1 and blocks its interaction with PD-1, thereby enhancing T-cell activity against tumor cells.21 Durvalumab (Imfinzi®) Durvalumab (Imfinzi, AstraZeneca, Cambridge, UK) is a human IgG1κ monoclonal antibody that blocks the interaction of PD-L1 with the PD-1 and CD80 (B7.1) molecules.25 Rower Michelle and Kleo 2 Link to comment Share on other sites More sharing options...
Tomm Posted June 25, 2019 Share Posted June 25, 2019 Hi Kelo, You really have an attitude of such a fighter and taking everything they toss at you and believing in your future. Positive forward thinking is a good thing for all of us. I am really sorry to hear your dealing with pain and I hope your team helps. I hope you have great success with your new protocol. Rower.. That's some nice research you did reading the Society of Oncology Association. (ASCO) abstracts. I'll try and read that too. Possible Durvalumab people: I want you to know that not everyone gets bad side effects but some that do are nice enough to share that information with us so we know what can happen and what to monitor. I am getting infusion #6 on Thursday, my thyroid is off THS 29.63 and I have fatigue and that's all. I have a Naturopath Oncologist that has me taking 18 natural supplements & coconut water. Other Durvalumab Patients: Please post that you are doing well or not and share that good and the bad, it will help others to know we are not alone. good luck fellow travelers Charles and Rower Michelle 2 Link to comment Share on other sites More sharing options...
Rower Michelle Posted June 26, 2019 Share Posted June 26, 2019 Thanks Tomm! If you Google June 2019 ASCO Abstracts you will get a home page with a searchable database. It’s a really useful search tool. Lung cancer is getting a lot of attention due to the emerging science. Let us know if you find anything of interest! 😀 Link to comment Share on other sites More sharing options...
Kleo Posted June 26, 2019 Share Posted June 26, 2019 Bob....you were right!😏 You called it! My onc won our little battle. and she basically told me I was being an idiot. 🤣 Said she is revoking my doctor's license, and having my google/internet cancelled. I tried saying...but the immunos all target the same thing that I don't even have...why bother? durva didn't work for me! She said that they are all entirely different drugs...using different pathways...and she really thinks this combo will stop my head stuff. Said I'm in alot better shape than I think I am. I said...but it's so toxic...you gave me 2,766 mg of drugs in 8 hours. Her eyes got real big and she said...you mean you actually sat there and added up the milligrams?!! Geeez. 😁 Yes I did. LMAO. Anyway...she's reducing my chemo doses since I really haven't any active cancer in the lung- and chemo is what makes me feel so crappy....so I'm gonna try it again. Bob was right....he's like Yoda. And as said by tomm here.....I am NOT typical for Durvalumab! It works wonderfully for most people! Robert Macaulay and Rower Michelle 2 Link to comment Share on other sites More sharing options...
Barb1260 Posted June 26, 2019 Share Posted June 26, 2019 Grouchy is acceptable. Sorry about the pain. I’ve only had 4 infusions and I have pain in my foot joints occasionally which I had for years then it went away during chemo and radiation. Never figured that out Link to comment Share on other sites More sharing options...
Barb1260 Posted June 26, 2019 Share Posted June 26, 2019 Kleo-never hit send on that one. Just found it. You made me choke on my boring turkey sandwich. Your doc must wait for your appointments, you’re the only bright spot in her day probably. Keep up your humor. Kleo 1 Link to comment Share on other sites More sharing options...
Robert Macaulay Posted June 26, 2019 Author Share Posted June 26, 2019 Kleo I been called lots names in my day but Yoda is not one of them.😁 Now i do like the statement your Doc made Said I'm in alot better shape than I think I am. Got to love female doctors I am biased as i have two😎.One other thing you mentioned I am NOT typical for Durvalumab! It works wonderfully for most people! But you were the norm rather than the exception but who is going to refuse a excellent drug even with the percentages. Now that you have given up studying Oncology you can enjoy the summer between treatments. Bob Kleo and Tom Galli 2 Link to comment Share on other sites More sharing options...
Jane Lee Posted June 27, 2019 Share Posted June 27, 2019 Hi Dura recipients Just thought I would give an update. I can hardly believe this. My lung specialist and the radiation specialist both consider that the tumour in the bottom lobe of the right lung has died from the radiation and chemo. But the radiation has caused that lobe to collapse so they can't actually see the tumour. I am assuming that because there is no sign that the tumour has spread or progressed that they think it is dead. Apparently. they do not do anything about the partially collapsed lung because it is too damaged from the radiation. Accordingly, the Dura kills any new tumours that might try to form because there is a very high likelihood of re-occurrence. At this stage, I refused to think about re-occurrence. What a shock, I read all these things on Dr Google about syringes and tubes to try to extrapolate the air or fluid in the lung to help it re-inflate and they don't do any of that in radiation cases - they just simply leave it alone. Wow, no oncologist for six weeks and the radiation specialist doesn't want to see me again. Only have to do the Dura once a fortnight and a blood test once every four weeks. It feels so surreal. I feel I am getting a second chance at life so I am staying on my current regime - no alcohol, no cigarettes, keeping processed foods to a minimum and as much walking as possible. They have even told me I can begin to lose weight (need it especially after putting on so much with the predisone). I actually wondering whether as a beginner to this lung cancer stuff that I am just being naive?????? Thank you all for your love, support and encouragement. It is so lovely to hear from people in the same predicament as yourself. I must have a look at all of the ASCO abstracts. Kind regards Jane Lee Charles, Kleo, Robert Macaulay and 3 others 6 Link to comment Share on other sites More sharing options...
Robert Macaulay Posted June 27, 2019 Author Share Posted June 27, 2019 Jane Lee Sorry to hear about the New condition. The good news is the doctors are letting you continue with Durvalumab as its main purpose is to halt the spread of cancer. I get blood work every two weeks prior to my infusion. The key is the three month scans when on this drug and if no progression you continue to the next three months CT.Walking is great way to get excercise everyday as i do with my dog seven days week.Bed time and bloodwork in the morning and docs in the afternoon. Bob Kleo 1 Link to comment Share on other sites More sharing options...
Tomm Posted June 27, 2019 Share Posted June 27, 2019 Jane Lee .. great news to hear your tumor is dead Kleo and Charles 2 Link to comment Share on other sites More sharing options...
Charles Posted June 27, 2019 Share Posted June 27, 2019 Jane Lee, Magnificent news !!!! Kleo 1 Link to comment Share on other sites More sharing options...
BridgetO Posted June 27, 2019 Share Posted June 27, 2019 Jane Lee, you're not being naive! You're living with hope and optimism. Good for you! It's great that your tumor is dead. Kleo and Charles 2 Link to comment Share on other sites More sharing options...
Kleo Posted June 27, 2019 Share Posted June 27, 2019 JaneLee….that is wonderful news! Go Durva go! Partially collapsed lung not included in celebration...but hopefully that'll resolve! Charles 1 Link to comment Share on other sites More sharing options...
Barb1260 Posted June 27, 2019 Share Posted June 27, 2019 Wonderful Jane. Great news Charles 1 Link to comment Share on other sites More sharing options...
Tom Galli Posted June 27, 2019 Share Posted June 27, 2019 Jane Lee, The beast is dead! Wonderful. Immunotherapy stops recurrence! Marvelous. Bet that partially collapsed lung resolves quickly. Enjoy life and... Stay the course. Tom Charles 1 Link to comment Share on other sites More sharing options...
Charles Posted June 29, 2019 Share Posted June 29, 2019 also a good update here the prednisone seems to be working it's wonders as the side effects are subsiding pretty nicely. Eye thing all but gone , abilities (physical, mental) seem to be improving, endurance improving, energy level coming back and lasting longer, and the overall feeling of "well being" returning with new creative thoughts emerging, this I thank God for. Last night, as my wife and I were having a discussion, I made a funny remark and we just howled and howled, complete with tears at 2 AM in the morning. I, full of energy, being a smoker for 40 yrs plus, and also having COPD, was once again able to laugh uncontrollably, with full breath without a coughing attack, which is something I have not been able to do in over a decade so I realized that, like Tom Galli described it above, This BEAST, and COPD had robbed me of who I was and I became overwhelmingly emotional and my wife and I cried and gave thanks to God and these treatments. I am scheduled for number nine on Tuesday with complete bloodwork and a visit with my Onc but do not know if I will be tapered off the Prednisone enough for the treatment but will be ready for treatment whenever I am, feeling better and soooooo greatful, thank you all......Charles Tom Galli, Rower Michelle, Barb1260 and 2 others 5 Link to comment Share on other sites More sharing options...
Barb1260 Posted June 29, 2019 Share Posted June 29, 2019 Glad to hear you are doing better. Happy for you. Stay positive Charles 1 Link to comment Share on other sites More sharing options...
Tomm Posted June 29, 2019 Share Posted June 29, 2019 Charles -->>> Great news!! Your a real fighter and a "I can take it guy" and it sounds like things are much better for you now...The future looks bright, you may need sunglasses.. Barb -->> How are you doing after #5? Me-->> I got #6 on thursday and just got some fatigue, going to the saturday farmers market today. Charles 1 Link to comment Share on other sites More sharing options...
Charles Posted June 29, 2019 Share Posted June 29, 2019 Tomm, thank you, hope you have a ball at the farmers market, last time I went to ours I couldn't breathe well enough to make it so we had to come home, may be tempted to try it again soon though, thanks for the idea..... Charles Link to comment Share on other sites More sharing options...
Barb1260 Posted June 30, 2019 Share Posted June 30, 2019 Hey Tomm. I’m good after #5. Just a little tired. I’m wondering if no real side effects means it’s not doing anything. PET/CT on Tuesday will let me know. Link to comment Share on other sites More sharing options...
Tomm Posted June 30, 2019 Share Posted June 30, 2019 Hey Barb. Our fatigue is real and it alters our lives, scanvity is a real side effect, living with hope is real too. There are about 20 people getting Durv where I get mine and they are all doing well with no one stopping from side effects. They told me that's the normal here. Stay hydrated and be happy your doing so well...I am Robert Macaulay and Charles 2 Link to comment Share on other sites More sharing options...
Rower Michelle Posted June 30, 2019 Share Posted June 30, 2019 Good luck on Tuesday Barb! It’s so great to see the Durva peeps doing well! Barb1260 1 Link to comment Share on other sites More sharing options...
Barb1260 Posted June 30, 2019 Share Posted June 30, 2019 Tomm-I am happy I’m doing well, I wish we can see the benefits other than a scan every 3 months. Michelle-thanks. I’ll have a slice for you next weekend. Rower Michelle 1 Link to comment Share on other sites More sharing options...
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