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Changing immunotherapy drug


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Hi, my mother in law has NSCLC that was diagnosed with Stage 3 NSCLC last October and has since had metastasis to her L4 vertabra and to her temporal bone.  The temporal bone tumor appears after 3+ months to have been successfully treated with a gamma knife radiation; the L4 tumor will be treated with radiation soon.  Her original tumors in her lung and lymph nodes appears to be gone after chemo/radaiation.   She has the KRAS mutation along with high PDL-1 and so she's on durvamulab.   

My question is whether given the mestastasis if anyone has experience changing immunotherapy drugs and found something else more effective. 

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