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PROBLEM: Not all cancer cells can be induced to undergo apoptosis (programmed cell death). Even when they do, the mere act of apoptosis can trigger the proliferation of cancer stem cells. Cancer stem cells can lead to distant metastasis, treatment failure, and disease recurrence.

SOLUTION: Target cancer stem cells by directly killing them and/or preventing them from entering a dormant and more resistant state.

PROBLEM: Instead of apoptosis, some cancer cells can be induced to enter a senescent or dormant state. Fortunately, senescent cancer cells permanently stop dividing, but unfortunately, they don’t die. They maintain cellular metabolism. This metabolism leads to the secretion of pro-inflammatory, cancer-causing compounds (also known as the “senescent secretome”). If enough senescent cancer cells accumulate, this can induce further growth and spread of cancer.

SOLUTION: Target accumulated senescent cancer stem cells by directly killing them and/or keep the senescence secretome under control.

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Hi there Dr Dan 

Thanks for taking the time to pull this information together   Can you elaborate on how one goes about developing the solution?  What questions should we be asking the oncologist? 

 

 

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