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jack14

CT scan results

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Well, I saw my Onc today and got the results of yesterdays CT scan. She had told me last week that she was not very optimistic that the Keytruda was working for me. She based that on the one lymph node that she can palpate which didn't feel as though it had shrank any, but had maybe even grown some.

She added that we would probably be switching to chemo therapy a day or so after the scan.

I had my first taste of "scanziety" and I sure didn't like it.

So, I get my blood drawn for my tri-weekly labs and vitals taken. And she walks in the room and, we are both wearing masks so I can't see her expression. Her eyes seemed to shine though and I was hopeful.

She sits down in front of me and says, "I have some good news", and tells me that the scan showed moderate but definite tumor regression in the primary lung nodule and in the two lymph nodes. So, we will continue with the Keytruda regimen.

whew.....thank you God. Please project this blesswing to my cancer brothers and sisters as well.

amen

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Great  news Jack. Any progress is good progress. Looking forward to even better results on your next scan so keep faith. Best of luck!

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Thank you everyone!  I wonder if anyone is doing any studies (subjective based) to try and determine why some people respond to Keytruda while others don't? For instance, I had a 20% PDL expression and some who have had more didn't respond to treatment, and others as low as one percent have. Anyway, I havn't been asked anything by any of my providers in regards to things that I may or may not be doing that could explain it.... just wondering. Diet, exercise, sleep quality, stress levels, etc. could be a factor.

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Imagine if someone was to discover that it was the folks who had been drinking chlorinated municipal water that failed to respond to immunotherapy. Or, who took medications for GERD, or maybe it's the mouthwash, toothpaste? How many lives would have been saved...pain and suffering alleviated.

Here is an interesting article I found that might relate this to gut bacteria. https://www.cancerresearch.org/blog/june-2020/microbiome-cancer-on-a-chip-hyun-jung-kim?utm_source=luminate&utm_medium=email&utm_campaign=cancerimmunews&utm_content=aug2020

And there is also a chance that there may be more than one thing that effects ones response to immunotherapy.....

 

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Hi Jack

Just catching up today.  Congrats on getting through scan #1.  No one likes scanxiety it totally sucks.   So glad it was good news.  I wish we knew more about why some people respond to treatment while others don’t.   Carry on!   We’re rooting for you! 
Michelle

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On 8/1/2020 at 2:49 PM, jack14 said:

Thank you everyone!  I wonder if anyone is doing any studies (subjective based) to try and determine why some people respond to Keytruda while others don't? For instance, I had a 20% PDL expression and some who have had more didn't respond to treatment, and others as low as one percent have. Anyway, I havn't been asked anything by any of my providers in regards to things that I may or may not be doing that could explain it.... just wondering. Diet, exercise, sleep quality, stress levels, etc. could be a factor.

Very good question but the answer is simple but not simplistic. First one needs to know how the human body functions.

Scientists have come a long way in estimating the number of cells in the average human body. Most recent estimates put the number of cells at around 30 trillion. Written out, that’s 30,000,000,000,000! These cells all work in harmony to carry out all the basic functions necessary for humans to survive. But it’s not just human cells inside your body. Scientists estimate that the number of bacterial cells in the human body likely exceeds the number of human cells. https://www.healthline.com/health/number-of-cells-in-body#:~:text=Humans are complex organisms made,Written out%2C that's 30%2C000%2C000%2C000%2C000!

Also imagine the cells do not function exactly the same way from one human to another. For instance I read an article lately that claims that the percent of PD-L1  in cancer patient does not determine the success or failure of Keytruda  but it is rather the manner in which PD-L1 interacts with PD1 and other cells.  There is more success currently fighting lung cancer because there are many solutions and oncologists  rely on other oncologists experience to choose the right regimen.

Profits and money in the pharma industry made it impossible in the past the share any information about new drugs, research or clinical trials. So there was no way the know for instance how Kytruda  given at the same time as chemo will benefit the patient.  Also clinical trials beside being kept  secret were very stringent so that a patient with lung cancer and COPD or any other condition will not qualify the enter the trial. Pharma wanted the perfect candidates.

8 years ago the Federal Government began a program demanding that all clinical trials be logged in the same data base and that all the results were shared among pharma, researchers and oncologists. Also the law states that every cancer patient treated for cancer also be part of a single data base. 

Modern computers are able to process as many instructions in one day as they use to. That enables researchers to compare results among cancer patients and equate them to their cells interactions. While the technology is just starting, it is estimated that few years from now oncologists will be able to pinpoint exactly what regimen fits each cancer patient. This is not only true for cancer but any other ailment. If you heard of personalized medicine  it was born from this concept.

As for what we consume daily there is no doubt personalized medicine will reveal  many surprises. This is a very brief description of what I learned from the internet after I become a cancer patient. I hope it helps.

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Thank you Michelle! I am rooting for all of you too.

And thanks Gary. Those are some truly interesting facts. I had heard about the sharing and integration of information and believe that will help us to see an end the death and suffering. I only hope that we see a breakthrough in regards to perfecting that "personailzed medicine" much sooner than later.

 

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