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MET Exon 14 Skipping treatment combination


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I am intersted in whether the combination of targeted therapy for MET Exon 14 Skipping (TABRECTA/CAPMATINIB) and immunotherapy (e.g Pembrolizumab/Keytruda) can be better as first line compared to Tabrecta alone. 

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Welcome here. I am not acquainted with the combination targeted therapy and immunotherapy you refer to. Here is the latest thing I've read about treating NSCLC Adenocarcinoma MET Exon 14 Skipping.

Stay the course.


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  • Abe changed the title to MET Exon 14 Skipping treatment combination
  • 4 weeks later...

Thank you for posting and sharing this article. Since I am new to the group, this information is very helpful & encouraging.

In 1996, at age 70, my father was diagnosed with LC & was told pretty much to pack his bags, get his affairs in order & go on hospice. Six months later he died a horrible death with excruciating pain when lc metastasized to his bones.

Fast forward, 25 years later with my sisters dx of BM nsclc, finding her gene mutation & being able to treat it with targeted therapy, help is on the way. Extremely encouraging. Thumbs up!!

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  • 2 weeks later...


Things have changed drastically in the past 5 years no less since 1996.  Please keep us updated and ask any other questions you may have.


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Sorry just found your post as I’ve not logged in for a few days. Thank you for your concern and encouragement.

Yes indeed, as I had no idea how many more advancements have been made in this field of LC.

it just seems so unbelievable that FDA just approved the targeted drug, Trabecta, just a few months before my sisters diagnosis of bm nsclc.

She received 2 weeks of WBRT in Dec.  Recent results of MRI indicated lesions shrinking, with no swelling in her brain. Yes!! She’ll have a scan from her head to pelvis next month. (for the lungs?).

She sounds hopeful & optimistic but does have some bad days & can get very fatigued especially in the evening.

Other than that, no swelling no other side affects except sometimes vertigo. A little nausea at times.

Finally she got the covid vaccine & will get 2nd shot in a few weeks. I’ll feel better when she’s fully vaccinated though. Didn’t understand why cancer patients & shutins weren’t a priority for the vaccines. Oh well!!


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I have not heard of using Tabrecta and immunotherapy combined together.  I did have Keytruda with Carbo and Alimta, then Alimta and Keytruda, then Keytruda alone.  The Keytruda was stopped at the end of December and now I'm starting Tabrecta - actually today.  My oncologist did say that Keytruda might be used again in the future, but he did not offer it with Trabecta.  

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