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Are you taking CISPLATIN ?

Donna G

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Neuroprotective Effect of Vitamin E Supplementation in Patients Treated With Cisplatin Chemotherapy

Andrea Pace, Antonella Savarese, Mauro Picardo, Vittoria Maresca, Umberto Pacetti, Girolamo Del Monte, Annamaria Biroccio, Carlo Leonetti, Bruno Jandolo, Francesco Cognetti, Loredana Bove

From the Neuroscience Department, Oncology Department, Experimental Chemotherapy Laboratory, Regina Elena National Cancer Institute and the Laboratory of Physiopathology–S. Gallicano Institute, Rome, Italy

Address reprint requests to Andrea Pace MD, Service of Neurology, Regina Elena National Cancer Institute, Via Chianesi 53, 00144 Rome, Italy; email: pace@ifo.it.

Purpose: The aim of this study is to evaluate the neuroprotective effect of antioxidant supplementation with vitamin E in patients treated with cisplatin chemotherapy.

Methods: Between April 1999 and October 2000, forty-seven patients were randomly assigned to either group one, which received vitamin E supplementation during cisplatin chemotherapy, or to group two, which received cisplatin chemotherapy alone. Alpha-tocopherol (vitamin E; 300 mg/d) was administered orally before cisplatin chemotherapy and continued for 3 months after the suspension of treatment. For preclinical studies, nude mice carrying the human melanoma tumor were treated with cisplatin alone or in combination with vitamin E.

Results: Twenty-seven patients completed six cycles of cisplatin chemotherapy: 13 patients in group one and 14 patients in group two. The incidence of neurotoxicity was significantly lower in group one (30.7%) than it was in group two (85.7%; P < .01). The severity of neurotoxicity, measured with a comprehensive neurotoxicity score based on clinical and neurophysiological parameters, was significantly lower in patients who were supplemented with vitamin E than in patients who were not supplemented with vitamin E (2 v 4.7, P < .01). The results of the preclinical studies showed that when cisplatin was combined with vitamin E, no differences were observed in tumor weight inhibition, tumor growth delay, or life span as compared with treatment with cisplatin alone.

Conclusion: Supplementation of patients receiving cisplatin chemotherapy with vitamin E decreases the incidence and severity of peripheral neurotoxicity.

Just thought I would post this. I have neuropathy from Cisplatin, wish I saw this study 6 + yrs ago. Donna G

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I know cisplatin is rough, I believe the amifosdine /ethyol also protected me from the worst of the neuropathy as well as the hearing loss and middle ear damage.

Just goes to show, every year, every MONTH, progress is being made on some front in the war against cancer.

I'm glad it isn't fifty years ago. My kids would be motherless.


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