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LUNGevity Blog - KRAS: How It Started vs. How It’s Going


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KRAS: How It Started vs. How It’s Going

Posted on April 21, 2022

Dr. Amy Moore and Dr. Upal Basu Roy

On May 28, 2021, the United States Food & Drug Administration (FDA) approved sotorasib as the first targeted therapy for patients with KRAS G12C-positive non-small cell lung cancer (NSCLC). Both researchers and patients celebrated this historic breakthrough, which had been a goal since discovering the KRAS oncogene 40 years ago. KRAS is a leading driver mutation in various forms of cancer. Still, targeting KRAS had failed for nearly four decades, leading many to believe that it was “undruggable.”

In the nearly one year since this first FDA approval, advances in the KRAS space have continued to grow rapidly. Here we reflect on the past year and look into our crystal ball to predict where this field is going.

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