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Brother might be heading onto 3rd line treatment


Good Bro

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So, after 7 months of Taxotere and Cyramza, I think there's a good chance my brother might be onto a 3rd line treatment.  Got his scan results back late last week and meets with his onc to go over them tomorrow.  However, he sent them to me to review and I didn't see the word "decrease" or "reduced" anywhere.  In fact, more than 10 of the lesions in his liver have increased in size and he has 2 new ones in the abdomen region (report didn't specifically state where).  Also mention of Pancreatic Atrophy.

Definitely not the results we were hoping for but maybe the oncologist will state that it's not as bad as it sounds.  That has happened before.  Anyway, crossing our fingers for tomorrow's discussion.  If they do switch up his treatment, hopefully this next one will be the one that finally works longer term.

Has anyone had some progression while on a treatment plan and your doc kept you on that treatment still?  Or, do they switch it at the first sign of any progression whatsoever?

 

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Anytime one hears about growth of lesions/nodules/tumors it's not a good thing.  But more important will be what the ONC has to say about the scans, potential treatments, and anticipated outcomes.  My prayer is for hope in the discussion and always remember; anytime your brother feels the need for a second opinion he should get one.

Lou

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Good Bro,

Has anyone had progression in treatment and remained on an unchanged treatment plan? Yes, I've had that situation. Do doctors switch treatment at the first sign of progression? That is a complicated question and my best response is it depends on a myriad of factors, way too complicated for me to elaborate on.

Be mindful of liver lesions. They come in two general flavors: hyper dense and hypodense. Interpretation of each type as to cause is an art form. The size increase may be caused by chemo agents. New abdominal lesions are of greater concern. Do you know the location of these?

Stay the course.

Tom

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Tom,

Do you know the location of these? - the report states Segment 4 (0.9cm) and 7 (0.6cm).

Good to know on the liver lesions.  The report did state that the lesions that increased in size were all pre-existing from scans back in January.  Some of those had showed some reduction in scans done between Jan and July but have increase in size during the latest scan.  Do you know which of the two (hyper vs hypo) are attributed to the chemo agents?

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Good Bro,

Segment 4 is likely a scan run (image) not an anatomical reference. And I wouldn’t know which of the two cited lesions expand given chemo agents. I recall my medical oncologist offering the expansion idea during one of my mid treatment scans. I was on Taxol and Carboplatin and several of my discovered lesions grew. They were back to “normal” after treatment   

Be sure to have the lesion and new growth issue explained by your dad’s physician. 

Stay the course. 

Tom

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Thx again Tom.  Of course.  My brother is actually currently getting bloodwork done as I type and will be discussing with his doctor and then supposedly getting his next treatment... that is if the doctor doesn't switch things up.  I do believe the "segments" in this case refer to the different areas of the abdominal region but not certain on that.  See image below:   

image.png.c37df8005bedcd83e74e63436715341f.png

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Just as I was afraid of... his oncologist confirmed that the growth in his liver is very concerning and he needs to switch up treatments.  So, onto the 3rd and final line of treatment.  If this doesn't work, he will need to look into clinical trials.  :(  

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