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looking for your advice on treatments I researched


LindaMRG

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Hello Friends,

I was online last night researching and came across things that I will ask my father's oncologist about on Friday, but I wanted to run it by you as well. First was Vitamin B17. It seems to be found in apricot seeds. It is supposed to be preventative for cancer and shrink tumors if you have cancer. The other thing is the vaccine. When does that come into play, when youve exhausted all options?

Thanks for anything you might know.

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Hi! B-17 vitamin, I think it is also referred to as laetrile. The negative side I heard is that it could produce a cyanide effect to a patient and can do them under much earlier than expected. Vaccines? I heard that a dendritic cell vaccine is very promising for lc pateints. I am trying to get my dad into a vaccine clinical trial. There are more options, look up L-arginine supplement. In some studies it has shown to produce tumor shrinkage. However, I know that in some cases where you givevery high doses it can help spread the cancer more. I dont know my dad has been on arginine for 4 days and seems a lot better. I will also get him started on the hoxsey formula, I heard good things about it. Bottom line it wouldnt hurt him, but could help him. At least it is giving hope to the patient! good luck

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Hi everyone, What is arginine? and Hoxsey? I was looking at the B-17 also for my husband. I found a news release on SU011248 in trials yet, but in France at the Institute Gustave Roussey. The trials are sounding very promising for cancers that just don't respond, I found it using AOL keywood SU011248. I am bringing it to the Doc this week. Carol

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What is L-Arginine? Here is some info I found.

Arginine

A positive study conducted by a team of German researchers showed that arginine contributed significantly to immune function by increasing levels of white blood cells. Scottish scientists added that dietary supplementation with arginine in breast cancer patients enhanced NK cell activity and lymphokine cytotoxicity (Brittenden et al. 1994). (Lymphokines are chemical factors produced and released by T-lymphocytes that attract macrophages to a site of infection or inflammation in preparation for attack.) Various researchers have shown that increasing arginine increases neutrophils (white blood cells that remove bacteria, cellular debris, and solid particles), significantly upgrading host defense (Muhling et al. 2002).

Apart from enhancing immune function, arginine increases a number of amino acids, creating the possibility of an amino acid imbalance. Oversupplying some amino acids while undersupplying others is thought to destabilize the tumor. All cells, both healthy and diseased, have amino acid requirements; if not met, the cell is significantly handicapped (Muhling et al. 2002). Amino acid manipulation has been applied in oncology for decades with varying degrees of success.

Interesting studies have emerged regarding arginine or arginine analogs in cancer treatment. For example, infusions of arginine significantly reduced the incidence of liver and lung metastasis in laboratory mice. Earlier research found that supplemental arginine altered the number of tumor-infiltrating lymphocytes in human colorectal cancer, offering important implications for new strategies in cancer treatment (Heys et al. 1997). Though many factors are involved (including appropriate dosages), Japanese researchers found that arginine induced apoptosis in pancreatic (AR4-2J) cells, inhibiting cell proliferation (Motoo et al. 2000).

Curr Drug Targets Immune Endocr Metabol Disord 2001 May;1(1):67-77

Immunoregulatory effects of L-arginine and therapeutical implications.

Potenza MA, Nacci C, Mitolo-Chieppa D.

Department of Pharmacology and Human Physiology, Section of Pharmacology, Medical School, University of Bari, Italy. potenza@farmacol.uniba.it

Arginine, initially classified as a non-essential amino acid, participates to multiple biological processes including release of several hormones, collagen synthesis during wound healing, antitumor and antibacterial activities and non-specific immunity. Nitric oxide synthase and arginase competes for L-arginine as a substrate and this event appears to play a key role in the regulation of the inflammatory process. In this framework recent studies have identified complex patterns of interactions among these enzymes. This review will emphasizes some effects of L-arginine on immune cell functions, including triggering of L-arginine-nitric oxide and arginase pathways, its biological properties and therapeutical applications.

Publication Types:

Review

Review, Tutorial

Hoxsey formula, there is plenty of info on the net. But basically this is a formula that has supposedly cured cancer. It's a mixture of many roots and plants. I will try it on my dad, it doesnt hurt to try and maybe my dad could one who benefits from this.

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http://www.cancer.gov/cancerinfo/doc.as ... c00b3c5f9f

Human/Clinical Studies

Laetrile has been used as an anticancer treatment in humans worldwide.[reviewed in 10] Although many anecdotal reports and case reports are available, findings from only two clinical trials [8,56] have been published. No controlled clinical trial (a trial including a comparison group that receives no additional treatment, a placebo, or another treatment) of laetrile has ever been conducted.

Case reports and reports of case series have provided little evidence to support laetrile as an anticancer treatment.[26,9,31,32,58,reviewed in 10] The absence of a uniform documentation of cancer diagnosis, the use of conventional therapies in combination with laetrile, and variations in the dose and duration of laetrile therapy complicate evaluation of the data. In a case series published in 1962,[31] findings from ten patients with various types of metastatic cancer were reported. These patients had been treated with a wide range of doses of intravenous Laetrile® (total dose range, 9 to 133 grams). Pain relief (reduction or elimination) was the primary benefit reported. Some objective responses (responses that are measured rather than based on opinion), such as decreased adenopathy (swollen lymph nodes) and decreased tumor size, were noted. Information on prior or concurrent therapy was provided; however, patients were not followed long-term to determine whether the benefits continued after treatment was stopped. Another case series that was published in 1953 included 44 cancer patients and found no evidence of objective response that could be attributed to laetrile.[29] Most patients with reported cancer regression in this series received recent or concurrent radiation therapy or chemotherapy. Thus, it is impossible to determine which treatment produced the positive results.

Benzaldehyde, which is one of laetrile's breakdown products, has also been tested for anticancer activity in humans. Two clinical series reported a number of responses to benzaldehyde in patients with advanced cancer for whom standard therapy had failed.[18,19] In one series, 19 complete responses and 10 partial responses were reported among 57 patients who had received either oral or rectal beta-cyclodextrin benzaldehyde; however, precise response durations were specified for only two of the patients.[18] Another series by the same investigators used 4,6-benzylidene-alpha-D-glucose, which is an intravenous formulation of benzaldehyde.[19] In this series, seven complete responses and 29 partial responses were reported among 65 patients, with response durations ranging from 1.5 to 27 months. No toxicity was associated with either preparation of benzaldehyde, and it was reported that the responses persisted as long as treatment was continued. Almost all of the patients in these two series had been treated previously with chemotherapy or radiation therapy, but the elapsed time before the initiation of benzaldehyde treatment was not disclosed.

In 1978, the NCI requested case reports from practitioners who believed their patients had benefited from laetrile treatment.[59] Ninety-three cases were submitted, and 67 were considered evaluable for response. An expert panel concluded that two of the 67 patients had complete responses and that four others had partial responses while using laetrile.[7] On the basis of these six responses, the NCI agreed to sponsor phase I and phase II clinical trials.

The phase I study was designed to test the doses, routes of administration, and the schedule of administration judged representative of those used by laetrile practitioners.[56] The study involved six cancer patients. The investigators found that intravenous and oral amygdalin showed minimal toxicity under the conditions evaluated; however, two patients who ate raw almonds while undergoing oral treatment developed symptoms of cyanide poisoning.

The phase II study was conducted in 1982 and was designed to test the types of cancer that might benefit from laetrile treatment.[8] The majority of patients had breast, colon, or lung cancer. To be eligible for the trial, patients had to be in good general condition (not totally disabled or near death), and they must not have received any other cancer therapy for at least one month before treatment with amygdalin. Amygdalin, evaluated for potency and purity by the NCI,[60] was administered intravenously for 21 days, followed by oral maintenance therapy, utilizing doses and procedures similar to those evaluated in the phase I study. Vitamins and pancreatic enzymes were also administered as part of a metabolic therapy program that included dietary changes to restrict the use of caffeine, sugar, meats, dairy products, eggs, and alcohol. A small subset of patients received higher-dose amygdalin therapy and higher doses of some vitamins as part of the trial. Patients were followed until there was definite evidence of cancer progression, elevated blood cyanide levels, or severe clinical deterioration. Among 175 evaluable patients, only one patient met the criteria for response. This patient, who had gastric carcinoma with cervical lymph node metastasis, experienced a partial response that was maintained for 10 weeks while on amygdalin therapy. Fifty-four percent of patients had measurable disease progression at the end of the intravenous course of treatment, and all patients had progression seven months after completing intravenous therapy. Seven percent of patients reported an improvement in performance status (ability to work or to perform routine daily activities) at some time during therapy, and 20 percent claimed symptomatic relief. In most patients, these benefits did not persist. Blood cyanide levels were not elevated after intravenous amygdalin treatment; however, they were elevated after oral therapy.[8]

On the basis of this phase II study, NCI concluded that no further investigation of laetrile was warranted.[61] However, several concerns have been expressed about the way the study was conducted.[reviewed in 5]

Variations in commercial preparations of laetrile from Mexico, the primary supplier, have been documented.[60,62] Incorrect product labels have been found, and samples contaminated with bacteria and other substances have been identified.[60,62] When a comparison was made of products manufactured in the United States and Canada, differences in chemical composition were noted, and neither product was effective in killing cultured human cancer cells.[28]

Adverse Effects

The side effects associated with laetrile treatment mirror the symptoms of cyanide poisoning. Cyanide is a neurotoxin that can cause nausea and vomiting, headache,[reviewed in 1] dizziness,[8, reviewed in 15] cyanosis (bluish discoloration of the skin due to oxygen-deprived hemoglobin in the blood), liver damage,[63,64] hypotension (abnormally low blood pressure),[31,reviewed in 1,3] ptosis (droopy upper eyelid),[65,66] ataxic neuropathies (difficulty walking due to damaged nerves),[67] fever,[65, reviewed in 3] mental confusion, coma, and death.[reviewed in 23,31,56] Oral laetrile causes more severe side effects than injected laetrile. These side effects can be potentiated (increased) by the concurrent administration of raw almonds or crushed fruit pits, eating fruits and vegetables that contain beta-glucosidase (e.g., celery, peaches, bean sprouts, carrots),[20,52,64,reviewed in 15,21] or taking high doses of vitamin C.[64,68,reviewed in 1]

Vitamin B17 was the subject of great controversy over 20 years ago when some of the world's top scientists claimed that when consumed, the components of the seed make it 100% impossible to develop cancer and will kill existing cancer in most cases. The pharmaceutical companies pounced on this claim immediately and demanded that FDA studies be conducted. The results of these studies are found in the book "World Without Cancer", by G. Edward Griffin. To order the book click here or call 877-479-3466.

Vitamin B-17, also know as Laetrile and Amygdalin is found in most fruit seeds... namely apricot seeds. The apricot seed was claimed as the cure for all cancers over 35 years ago.

It was even more strongly claimed that when one eats about 7 apricot seeds per day they can never develop cancer, just as one can never get scurvy if they have an orange every day, or pellagra if they have some B vitamins every day.

The pharmaceuticals companies together with the medical establishment pushed the FDA into making it illegal to sell "raw" apricot seeds or vitamin B17 with information about its effects on cancer. Even to this day, you can't get raw apricot seeds in your health food store, only the sun dried ones which have all the important enzymes killed off.

Pharmaceutical companies only conduct studies on patented chemicals they invent so that at the end of their study, if the drug gets approved, they have sole rights on its sale. (They make back tons more than the mere 250 million that they invested) They never do studies on foods that can't be patented and that can be sold by any supermarket.

The information on this site is not just for preventing cancer, it is for those that have cancer now and are on chemo or radiation at this moment, as well as for those who have cancer but haven't started any conventional methods yet.

Most of the people that already have cancer clusters in their body, who eat the apricot seeds and/or take the vitamin b17 in tablet form show near to complete tumor regression. Although cancer patients may get rid of their cancer, they also have the problem of the organ damage that the cancer has caused. This is another issue where other herbs and remedies are necessary for proper organ regeneration. Of course when a person's body is completely eaten up by cancer, the apricot seeds and its extract (laetrile and vitamin b17) would only prolong their life many times longer than chemotherapy and might not completely save them. However in many cases high levels of the injectable laetrile will help a great deal with the pain.

From the site http://www.1cure4cancer.com

Why are Laetrile and many other substances used in alternative-cancer therapy not readily available in the U.S.?

The short answer is that these substances are not approved by the Food and Drug Administration. The full answer, however, is a bit more complex. The reason they do not carry approval is that they have not undergone the extensive FDA testing that all new drugs must pass before being approved for common use. That’s the law in the United States. This process takes years of research work, requires tens of thousands of pages of reports, and costs hundreds of millions of dollars. The only firms that can afford this are large pharmaceutical companies. Not even they will undertake such expense unless they can eventually make a profit through sales, and that means they must obtain a patent on the substance being tested. However, substances found in nature cannot be patented, only man-made chemicals and processes can. Since Laetrile and many other substances used in alternative-cancer treatments are found in nature, they cannot be patented. That means they will never be tested according to FDA protocol. Consequently, they will never be officially approved no matter how effective they may be. That is why you often hear it said that alternative cancer therapies are "unproven." That is a very misleading statement. They may not have been proven by FDA protocol, but many of them definitely have been proven as both safe and effective by actual clinical experience in the treatment of thousands of cancer patients. Unfortunately, until the laws are changed, the only officially approved substances we will ever have for the treatment of cancer in the United States are man-made, patented chemicals!

From http://www.cancure.org/unapproved_by_FDA.htm

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