john Posted June 9, 2003 Share Posted June 9, 2003 Not sure how accurate this article is ... " ... The molecular mechanisms by which tumor cells degrade bone involve tumor cell adhesion to bone as well as the release of toxic chemicals from tumor cells that stimulate osteoclast-induced bone degradation. Bisphosphonates inhibit both cancer-cell adhesion to the bone matrix and (as noted) osteoclast activity. By preventing tumor cell adhesion, biphosphonates are useful agents for the prophylactic treatment of patients with cancer that is known to preferentially metastasize to bone. There is evidence that growth factors such as insulin-like growth factor and transforming growth factor are released when the bone matrix is degraded. These growth factors could stimulate tumor cell proliferation throughout the body, which may be a reason that early use of clodronate has significantly improved survival. ..." http://www.lef.org/magazine/mag99/jan99-cover.html Quote Link to comment Share on other sites More sharing options...
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