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Gemzar < - > carboplatin admin. order


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Just had Gemzar and Carboplatin yesterday (started a new treatment), perviously I had had Taxol and Carboplatin. Carboplatin was always given 2nd in both instances. Don't know why. Had a allergic reaction to thr Carbo yesterday (won't be having that anymore), had everyone excited again in the infusion room!

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Andrea Posted: Tue Sep 28, 2004 1:28 pm Post subject:


Not quite sure if the order matters, but FYI my mom had Carboplatin/Gemzar week 1; Gemzar week 2; week 3 off


I'm asking about the order in which the 2 drugs are given when both are given during the same treatment session ( i.e. gemzar then carbo or carbo then gemzar ). IMO the order shouldn't matter. But, recently I did hear someone comment that it does matter so I thought I'd ask if anybody else had heard anything regarding this.

P.S. FWIW my wife has always received the Gemzar last.

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I don't think it really matters. With carboplatin and taxol there is some evidence that the taxol should be given first. I found these articles on carbo/gemzar:

This one suggests no clinical difference with sequence in humans

http://www.ncbi.nlm.nih.gov/entrez/quer ... s=10201516

This one suggests that in petri dishes, gemzar first works better

http://www.ncbi.nlm.nih.gov/entrez/quer ... s=11561780

We usually give gemzar first but I don't think it makes a difference.

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