I joined last June, but this is my first post. I'm 62, dx January 2016. Stage 4 nsclc, adeno, pleural effusion, inoperable 3cm tumor & sub-centimetre nodules in both right & left lungs. No mutations. PDl-1 positive 80%. After the initial pleural effusion was drained right upper the lobe remained collapsed. Treatment was 4 Carbo/Alimta, 2 rounds of radiation & Alimta maintenance X 5. Some Pleural effusion always lingered on scans while the 3 cm & the sub-centimetre responded . In August I was hospitalized for pneumonia & pleural effusion, then immediately after I was diagnosed with pneumotitis. I was off treatment for 4 months., last Aug12. SOB & rapid heart rate started with the pneumonia. SOB improved -EKG was normal in September, but rapid heart rate remained, usually 115 on exertion, 100-105 at rest. Onc explains it's because of the disease my heart is working harder. Climbing stairs in our home always challenging. While on prednisone for pneumotitis SOB returned in mid-November due to a pleural effusion, drained. Then another, drained. Tapered off prednisone, chest tube inserted for pleural effusions Dec 7. . Regular drains now every 2 days. Started Keytruda Dec15. Rapid heart rate remains, has been 135 on exertion. At rest 105-115. SOB Did not improve with chest tube as it was supposed to. Oxygen was recommended due to Change in my O2. Since chest tube was inserted o2 is tracked by visiting home nurse & is down to 90. On exertion lower with rapid heart rate. 2nd Keytruda January 6. I do not feel any side effects from Keytruda. My SOB has just declined. My last CT - right lung was difficult to see due to a pleural effusion, left lung has some spots. My onc was onc was on vacation my last visit & I will see home this week along with pulmonary. However, since my September scan the right lung is not getting much air & is operating at about 10%. I am wondering if anyone has had these problems. At first I was using oxygen for exertion, now I'm using it all the time due to changes to more changes in o2. Can I become oxygen reliant? I only do the stairs once a day Very slowly. Thanks, much appreciated.