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I joined this forum because my mom is recently diagnosed with lung adenocarcinoma in China. It is a big shock to me and my family since she never smoked in her 70-year of life and we never had a relative who had any forms of cancer. My dad is a life-long smoker though. Cancer seemed so far away to me before and suddenly it is just right in front. I have done a lot of online research last month and it is still a lot to take. I want to be more informed about lung cancer and its latest treatment through this community, and want to be part of group of people with similar experiences.
My mom was coughing for over a month and went to see the doctor in early June. The CT scan showed a tumor in lower right lung about 3 cm in size. She then had PET CT, MRI, bone scan, and enhanced CT. None of those showed the cancer has spread. However, during the micro invasive surgery, the doctor found out the cancer has spread to the upper and mid right lung and stopped the surgery without touching the tumor, but did took small piece of tissue with a spread dot for biopsy and genetic testing. The genetic test of blood showed nothing. But the genetic test of the tissue sample showed EGFR 19-Del mutation.
Her doctor prescribed Gefitinib (Iressa) for her first line treatment last week, saying her mutation responds very well to Gefitinib. However, i read that NCCN guideline is to use the 3rd generation TKI, Osimertinib (Tagrisso), as the first line treatment for EGFR mutation. Not sure if anyone here can shed some light here that which one is a better option.
Also, I live in New Jersey. Are there any local groups in either New Jersey or New York that i can join?
Hi, I know this is an old thread but I wonder if any of you had advice re KRAS and Stage IV NSCLC. My mother-in-law was diagnosed October 2018 with Stage 3, N2, underwent chemo-radiation for 6 weeks. In January she started durvamulab. In addition to KRAS, she has a very high PDL1 expression (90%), but was not a smoker.
Her lung tumor and lymph nodes now appear clear, but she had metastasis to her skull identified in May and now appears to have mets to her L4, which will be treated with targeted radiation, and may have another bone tumor in her skull. Her oncologist is considering whether to change her immunotherapy drug as durva hasn't seemed to have helped as well as whether another round of chemo may be warranted.
Curious if there was any connection between Opdivo and KRAS; or if you have any insights into KRAS related trials that could be worth considering. We're in NYC, but I wonder if there's non-NYC institutions we should be connecting with.
Thanks so much for reading. Sending lots of love and best wishes
You landed in the right place with many other prayer warriors. The best thing about your post is treatment options, there have been more advances with lung cancer treatment in the last five years than the last 50. There are lots of options available to provide a high quality of life. The science is on our side, regardless of the Stage. Let us know what the proposed treatment plan is, we’ve got a very diverse, warm and caring group here.