My dad is on very large doses of these drugs. He has stage IV adeno with one large nodule in left lung, mets to lymph nodes, adrenal gland (PET scan shows activity), and possibly pelvic bone. He receives his chemo every three weeks. They give him 475mg of Taxol, 460mg of Carbo, and 1275mg of Avasting. These are very large doses. Is this normal? He is only three days out. He was doing absolutely great until tonight when he developed a very painful headache and he had some pains in his legs. He is very fatigued. I don't know what to expect. I know initially he handled it very well.