Cary Posted August 29, 2003 Share Posted August 29, 2003 I was wondering if everyone was aware of the drugs you should avoid while on iressa. Some cause the Iressa to be processed to quickly (inducers)making it ineffective while some make the process to slow(inhibitors) and make the side effects more severe while making the iressa ineffective also. I found this out from the FDA and AstraZeneca (makers of Iressa). There are over 150 conventional drugs that cause these interactions and to name a few Tagament, Phenobarbital, glucosteroids and Erythromycin. Also a lot of herbs and supplements are also processed the same way.(my father has recently stopped his supplements). The pathway these drugs and Iressa use is called CYP3A4. you can read the FDA report at the link below. http://www.fda.gov/ohrms/dockets/ac/02/ ... Zeneca.pdf Cary Quote Link to comment Share on other sites More sharing options...
Fay A. Posted August 30, 2003 Share Posted August 30, 2003 I used Iressa as part of a clinical trial. CYP3A4 is a liver enzyme, and we were given a long list of drugs to avoid while using Iressa. When in doubt, I would call Astra Zeneca directly. Faster than trying to get through to the pharmacist. Fay A. Quote Link to comment Share on other sites More sharing options...
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