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Study KT-220: Natural-occurring Anti-cancer Heart Hormones


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Kalos Therapeutics, a privately held biopharmaceutical company developing the Atrial Natriuretic Peptide (ANP) family for the treatment of human cancers, announced that David L. Vesely, M.D.,Ph.D., (University of South Florida) presented additional positive xenograft data today at the Experimental Biology 2008 Symposium on Heart Hormones. The data confirmed and expanded pre-clinical studies establishing the anti-cancer effect of this family of peptides naturally expressed in the human heart.

Dr. Vesely had shown that the ANP family of peptides has very broad activity in animal models, inhibiting the growth of all of the cancers examined to date: human pancreatic, lung, and breast cancers. The additional studies reported at the Symposium were performed by TD2, an oncology drug development contract research organization affiliated with the

Translational Genomics Research Institute (TGen, Scottsdale, AZ), and focused on the most active member of the ANP peptide family that is designated KT-220. These studies were designed to extend Dr. Vesely's previous findings by using a more challenging pancreatic tumor model system and including an additional, more aggressive type of pancreatic cancer. The results showed that KT-220 also has significant activity in these models.

Kalos Therapeutics holds an exclusive, worldwide license to a 2005 patent resulting from the pioneering work of Dr. Vesely, at the University of South Florida's Cardiac Hormone Center. The patent covers the use of this family of cardiac hormones as cancer therapeutics. Dr. Vesely now serves on Kalos' Scientific Advisory Board.

Dr. Norrie Russell, president and CEO of Kalos, said, "We are very encouraged by these study results, particularly in light of the National Cancer Institute analysis showing that an anti-cancer compound's breadth of activity in xenograft animal models is the best predictor of activity in human clinical studies. Based on these findings, and on the previous safe administration of KT-220 and other ANP family members to humans for another indication, we can confidently move forward with clinical development. Kalos is currently raising capital from institutional investors and qualified private individuals to initiate clinical trials of KT-220 in cancer."

KT-220 and the other peptides of the ANP family exert their anti-cancer effects through a novel mechanism involving the inhibition of the Mitogen Activated Protein Kinase (MAPK) signaling pathway, a key mechanism in cancer cell proliferation. These peptide hormones selectively shut off the proliferative effects of this kinase pathway in cancer cells but not in normal cells.

About the ANP Family of Peptides

The ANP family of peptides consists of four peptides derived from the pro-ANP gene, and includes ANP itself. These peptides, which share certain structural features, act through cell surface receptors to produce their antiproliferative effects. These peptides occur at the highest concentration in the heart, and much lower levels throughout the body. High natural levels of ANP peptides in the heart may be responsible for the low incidence of metastatic as well as primary cardiac tumors.

About Kalos Therapeutics

Kalos Therapeutics is a biopharmaceutical company that in-licenses, develops and commercializes proprietary product candidates primarily for the treatment of cancer. The ANP family of peptides represents a portfolio from which many drugs can be developed addressing multiple indications within cancer and non-malignant hyperproliferative disorders.

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(Medical News Today, Lung Cancer/Oncology, April 11, 2008)


The information contained in these articles may or may not be in agreement with my own opinions. They are not posted as medical advice of any kind.

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