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Going Back to TKIs After A Break

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My wife was on Brigatinib when it was in the clinical trial stage. The drug was great for her for over 2 years. 

Then it stopped working and we've been trying a whole bunch of other treatment since 2017. 

Has anyone had experience of going back to a TKI (e.g. Brigatinib or Alectinib) after a break (e.g. several months to a year) to find that the tumours respond to the drug again? 



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