@Karen_L @GBean I’m glad I stumbled on this forum. My husband was diagnosed with stage IV EGFR Kung cancer - that spread to the brain and spine in 2021. Was on 80 mg of Tagrisso for a year - no issue then the cancer spread - brain and bones. He had WBRT this past August and recently had shoulder replacement surgery. The cancer had spread to his humerus. Recent scans show a spread in lungs and adrenal glands. We too are contemplating increasing Tagrisso dosage or started Chemo. My husband is very weak from the WBRT and shoulder surgery- but he wants to fight this. We have young children.