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Insulin Potentiation Therapy

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Guest Michael

Your message prompted me to look into this procedure. I found a website www.IPTQ.com. It was developed in Mexico by a Dr. Garcia 70 years ago. There are 69 Doctors in 26 States who use this procedure. I plan to do more research. The procedure is also listed in www.cancure.org under Therapies. Sorry, but I don't know of anyone who has had this procedure but obviously many have. The website is quite interesting. I'll post back when I learn more.

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  • 4 months later...

Never retired, alert and otherwise active and vigorous 81 1/2 year old father (pipe smoker) was diagnosed with Stage III or IV Non-Small Cell Lung Cancer (adenocarcinoma and large cell) in late November, 2003 coupled with pneumonia and congestive heart failure (including swollen feet and ankles). (Fatigue and coughing up blood noticed in Oct. 2003). Confirmed malignant tumor in right main bronchus (hilar area) in excess of 3 cm and additional groups of confirmed cancer cells in left lung plus unbiopsied suspect shadow on liver. Also, massively swollen right arm on account of Superior Vena Cava syndrome or similar compression of subclavian blood vessel by tumor. The traditional physicians understandably recommended against regular chemotherapy due to cardiac weakness and recommended palliative-only radiation to shrink tumor in order to ease arm swelling and help clear pneumonia by clearing main airway of right lung of the blocking tumor. In lieu of recommended radiation (in order to avoid risks of radiation therapy including pneumonitis and in order to tackle wider spread cancer immediately through chemotherapy), family including patient decided to and did proceed with 6 biweekly administrations of lower-dose (more cardiac friendly) IPT as outpatient during December, 2003. Presently, condition is dramatically improved and he plainly appears to be no longer on death's immediate door step. Foot and ankle swelling completely gone. Pneumonia gone, having cleared from oral antibiotics and nebulizer treatments while IPT administrations were ongoing. Swollen right arm almost back to 100% of normal with rapid improvement after 5th IPT session involving change of mix of chemo agents. Supplemental oxygen presently (1/8/04) down to 3 liters from 5 or greater. 1.5L of non-malignant pleural effusion removed from lining of right lung by ultrasound guided throracentsis on 1/5/04; additional estimated 1.5L to be removed on 1/12/04. No more breathless spells. Appetite has returned. Traditional physicians are surprised at improvement without radiation or standard high dose chemotherapy. IPT, after change of mix (upon which arm size reduction and improved breathing first became observable), used a modified "triplet" of chemo agents (identified by five or more European NSCLC non-IPT clinical trials as having remarkably high 70-75% objective response rates and increasing median life expectancy to a range of 16-24 months) but at significantly lower doses to minimize side effects (did have suppression of white blood cell production requiring administration of Neupogen) plus COX-2 inhibitor. Also using Paw Paw Cell-Reg alternating with Co-enzyme Q10. Patient is likely to resume office desk work in the next week or two if progress continues. That possibility could not have been imagined on 12/4/03 upon discharge from hospital after 1 1/2 weeks as inpatient. Confirming CT and/or PET scans to be taken shortly and next round of IPT administrations also to begin. We feel prayers have been answered.

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  • 2 months later...

I received an e-mail request for an update on my almost 82 year old father suffering from advanced stage NSCLS who has been receiving IPT (insulin potentiation therapy). Significant improvement was observed through 1/15/04 after the completion of the first three week cycle of IPT on December 23. Supplemental oxygen was down to 2.5 liters from 5 liters upon release from hospital in early December. January 15 was the zenith of improvement since diagnosis in late November. IPT did not resume until 1/15/04 due to unexpected myelosuppression (probably from the unusual "quad" mix of chemo agents) and time to recover.

When the second three week cycle of IPT began on 1/15/04, breathing difficulties were immediately noticed especially during the day of and the two days after administration of IPT using the same mix as in late December. Paclitaxel was deleted from the mix and appears to have been the prime suspect for the apparent breathlessness side effect. However, the overall trend of health, which peaked at 1/15/04, was gradually but noticeably downward through early March. Breathing continued to worsen to the point that at times home oxygen concentrator and portable unit were both used to supply 8 liters of oxygen until breathlessness eased.

Recognizing that the IPT appeared to be losing its initial effectiveness, in early March the mix of IPT chemo agents was again altered, this time to a doublet of Cisplatin and Hycamtin (apparently more typically used for SCLC), and there was added daily intramuscular injections of the experimental drug Anvirzel. Also, the frequency of IPT was reduced from twice per week to weekly. These changes have reversed the downtrend and father's health improved significantly between March 9 and March 16 and now appears to have stabilized. Supplemental oxygen is at 4-5 liters, not as good as at 1/15/04, but better than during the February decline from which partial recovery has been made. Still very mentally alert and in no pain. Gross right arm swelling present during November hospitalization and through mid-December has not returned, suggesting that the size of the main tumor was successfully attacked to some degree without radiation by the IPT and that the tumor remains smaller than at time of diagnosis. Father has been able to attend monthly Board of Director meetings and participate actively from his wheelchair (muscle atrophy has occurred during the course of the illness such that he has become less ambulatory) accompanied by his portable oxygen unit. We're hoping that the IPT coupled with Anvirzel and Celebrex as a COX-2 inhibitor will continue to keep the cancer from progressing. Two attempts in late December and mid January to objectively remeasure the main tumor mass by CT scan failed first due to fluid build-up in the linings of the lung and then failure of the lung tissue to rebound after thoracentesis was performed. Thoracentesis is performed as necessary to control the fluid build-up. The most recent interval between thoracenteses lengthened somewhat to 3.5 weeks. We have not yet attempted another CT scan. PET scan performed in January shows cancer still active in lungs but no apparent metastasis to other organs (brain not checked by that PET scan).

Overall conclusion: Presently better than during November hospitalization or initial home care during early and mid-December. Family’s unanimous feeling is that without IPT he likely would have died by 12/31/03 based upon very bad and rapidly worsening condition from late November to mid December. Presently not in as good a condition as at January 15 but condition appears stable after partial recovery from the late January-February downturn.

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