RandyW Posted June 3, 2008 Share Posted June 3, 2008 Lung cancer: Cetuximab and platinum chemo Published: 02/06/2008 - PDF Version (81 KB) Cetuximab plus platinum-based chemotherapy improves survival for patients with newly diagnosed advanced lung cancer A large phase III study announced in Chicago at ASCO 2008, has found that the targeted therapy cetuximab (Erbitux), combined with platinum-based chemotherapy, is effective as a first-line treatment for patients with advanced non-small cell lung cancer (NSCLC). This is the first time a targeted drug has shown a survival benefit as a first-line treatment for patients with NSCLC, including all subtypes of the disease. Lung cancer is the leading cause of cancer death among men and women, with 161,840 lung cancer deaths expected this year in the United States alone. NSCLC is the most common type of lung cancer, comprising 85 to 90 percent of all cases; more than 80 percent of NSCLC patients have tumours that express the EGFR gene. For patients with the most advanced form of the disease, one-year survival is about 30 percent and five-year survival is just 1 to 2 percent. "Patients with advanced NSCLC have limited treatment options and life expectancy is short, so the survival increase shown in this study is an important step for these patients" said Robert Pirker, MD, an associate professor of medicine at Medical University of Vienna in Austria and the study's lead author. "These results clearly establish cetuximab in combination with chemotherapy as a new standard in first-line treatment of NSCLC." This study evaluated the addition of the EGFR antibody cetuximab to platinum-based chemotherapy (cisplatin and vinorelbine). The current standard of care for newly diagnosed patients with advanced NSCLC is platinum (either cisplatin or carboplatin) combined with a 'third-generation drug' (vinorelbine, gemcitabine, paclitaxel or docetaxel). Earlier studies of different EGFR-targeted drugs, also called tyrosine kinase inhibitors (gefitinib and erlotinib), did not to show an additional benefit to first-line standard chemotherapy and are currently approved for patients whose initial chemotherapy has failed. In this study, 1,125 patients in 30 countries were randomized to receive either chemotherapy alone (568) or chemotherapy plus cetuximab (557); 94 percent had stage IV disease (meaning the cancer had spread to other parts of the body). Overall survival was higher for those who received cetuximab plus chemotherapy (11.3 months) compared to those receiving chemotherapy alone (10.1 months). Additionally, the response rate was better in the chemotherapy plus cetuximab arm (36.3 percent) versus chemotherapy alone (29.2 percent). The benefit of cetuximab was seen in patients with all histological subtypes of NSCLC, including adenocarcinoma and squamous cell carcinoma, the two most common subtypes. Other targeted therapies for lung cancer have only proven effective against certain subtypes. As expected, the most frequent side effect was an acne-like rash, which was manageable with medication. Moderate rashes were seen more frequently in patients receiving cetuximab (10.4 percent) than in patients receiving chemotherapy alone (0.2 percent). The authors state that based on these findings, there will be more studies evaluating cetuximab in earlier stages of the disease, such as in combination with chemotherapy or chemoradiotherapy in patients with locally advanced disease or as an additional treatment after surgery in patients with early-stage disease. 04 June 2008 UK cancer research cited more often 03 June 2008 Revlimid for multiple myeloma 03 June 2008 Firefly gene for cheaper pre-clinical experiments 02 June 2008 Chemo for testicular cancer 02 June 2008 New treatment strategies for women with early-stage breast cancer - should we draw a line under the tamoxifen era? 02 June 2008 Lung cancer: Cetuximab and platinum chemo 02 June 2008 Narcolepsy drug for cancer fatigue 02 June 2008 KRAS predicts response to cetuximab for CRC 02 June 2008 Avastin and docetaxel combo slows cancer growth in new patients 02 June 2008 Bone loss drug reduces breast cancer recurrence News Archive » back to top | privacy statement Quote Link to comment Share on other sites More sharing options...
CaroleHammett Posted June 5, 2008 Share Posted June 5, 2008 Hi, Randy. Thanks very much for the posting. These articles and trial result postings on Erbitux (cetuximab) are of particular importance to me due to the positive responses for Squamous Cell Carcinoma (which has much more limited 2nd line options than adenocarcinoma). I should have read all postings before posting myself as this is yet another that falls under the Erbitux (cetuximab) heading, about which see also http://lungevity.org/l_community/viewtopic.php?p=358811 Carole Life is a Terminal Condition Quote Link to comment Share on other sites More sharing options...
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