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EGFR mutations on exon 20 and exon 21


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Hello everyone,

I'm 42M, and I've just been diagnosed with stage 4 lung cancer.

My PD-L1 is between 30 and 40%, and I have EGFR S768I (exon 20) and EGFR L858R (exon 21) mutations.

Is it normal to have more than one EGFR mutation? I'm starting treatment on osimertinib, how effective is this treatment?

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Hello and Welcome

The trade name of your drug is Tagrisso, it is very effective in treating EGFR NSCLC.  It’s not uncommon for some to be taking an EGFR inhibitor for more than ten years in the US.  You’re lucky in Portugal to have access to the newest inhibitor.  

As for the mutual mutations, it’s uncommon but not unheard of.  There’s a very active EGFR group on Facebook, if you have access then you’re likely to find others.  

Tagrisso works very quickly, in as little as a few days or a few weeks.  Hang onto your hope, the science is moving quickly with many more treatments in the future. 


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