JonathanS Posted October 22, 2004 Share Posted October 22, 2004 Hi everyone, For those of you who do not know me, my name is Jonathan and I am into oncology research, and currently in my 4th year of nursing school. My area will be oncology research nursing hopfully here at the University of Chicago Hospitals. Anyway, as I research for better treatments I must wonder a few things about sclc... 1.) What is the best first line therapy? A.) cisplatin/carboplatin with etoposide B.) cisplatin/carboplatin with CPT-11 Studies have shown a benefit in survival and long trem remissions with choice "B" in extensive staged patients, however, shouldn't that also carry over to limited staged automatically?? I mean if regimen "B" is better for late staged disease, wouldn't it automatically be better for early staged patients as well? 2.) Are there any studies looking at combining all three agents in first line therapy (cisplatin/carboplatin with etoposide and CPT-11)?? 3.) Drug resistance is the biggest problem with sclc, so why not alternate drugs before it is necessary. Like this example... cycle 1: give cisplatin with cpt-11 cycle 2: give cisplatin with etoposide cycle 3: give taxol with cisplatin this way the cancer cannot build up an immunity to the drugs as it being hit roughly at the same time with different agents. It will nto know what hit it or what to expect next in other words. Has there ever been a study like this? Is there a rationale here? 4.) Does gemzar play a role in sclc, and if so what role? 5.) After a pt goes into remission, why not resect the area of the lung the tumor began in --either the lobe or the wegde resection to eliminate the source of the disease. I know that surgery has been reseached way back, but not recentley with sclc, and we really do have better drugs and techniques today-so why not explore surgery again -either before or after remission?? Thanks for any answers you can give me....I know these are had questions, and I am honored to have an oncologist such as yourself help me answer them....Thnaks Dr. Joe we need you here!!! Jonathan Quote Link to comment Share on other sites More sharing options...
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