tnmynatt Posted November 21, 2004 Share Posted November 21, 2004 Do you know anything about MD Anderson's research into nanoparticles to deliver genes intravenously? I spoke to the head of the cancer gene therapy program and he thinks Charlie may qualify for this treatment. Your expert assistance is greatly appreciated. Take care. Quote Link to comment Share on other sites More sharing options...
kimblanchard Posted November 23, 2004 Share Posted November 23, 2004 Boy I can't tell you much about this one. I'm assuming this is a Phase 1 trial? I don't really understand nanoparticles, my impression is that they are a type of synthetic vector to introduce a gene like P53 tumor suppressor into someone with cancer. I've not seen any human trials reported with this so I really can't tell you much. I'm assuming this is really experimental so as always read the fine print. Quote Link to comment Share on other sites More sharing options...
teresag Posted November 23, 2004 Share Posted November 23, 2004 I searched http://clinicaltrials.gov and found this link to a trial at Sloan-Kettering: http://clinicaltrials.gov/ct/show/NCT00073723?order=2 and this one that appears to be only at NIH (Maryland): http://clinicaltrials.gov/ct/show/NCT00092261?order=1 Nothing came up at M.D. Anderson. Both trials refer to a nanoparticle formulation of paclitaxel. At the bottom of the pages linked above is contact information for the trials. - Teresa Quote Link to comment Share on other sites More sharing options...
tnmynatt Posted November 23, 2004 Author Share Posted November 23, 2004 Thanks Joe and Teresa. We heard back from MD Anderson today--the Gene Therapy Cancer Research Program. They are sending information for us to look at while Charlie is going through treatment with Alimta. You'll hit it pretty close based on my lay research. The nanoparticles are a new way of delivering lots of different things including chemo. drugs, gene materials, imaging materials to help see smaller tumors by MRI/CT, asthma medication, etc. Sounds very promising. Tests using the gene therapy in mice have been very promising and it is in Phase I trials. The use of Taxol in nanoparticles is also in trials. Thanks again for your help. I'll let you know what else we find out along the way over the next few months. Take care. P. S. It is so awesome having you'll here for us to talk to. Quote Link to comment Share on other sites More sharing options...
john Posted November 23, 2004 Share Posted November 23, 2004 This one has not made it out of the lab yet, but it is from austin and associated with MD Anderson. http://ww3.komotv.com/Global/story.asp?S=2548272 Quote Link to comment Share on other sites More sharing options...
tnmynatt Posted November 23, 2004 Author Share Posted November 23, 2004 John, Thanks. I think this is the one they are talking about at MD Anderson. Apparently, they have started Phase I trials. I will update you'll when we get the information they are sending us. Take care. Quote Link to comment Share on other sites More sharing options...
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