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epirubican and irinotecan


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Just got results of CT scans, MRI and PET yesterday, and not so good news. Several small spots on left lung, spine, ribs and a large one on right femur. I will be starting a clinical trial tomorrow with epirubican and irinotecan. Has anyone ever used these and if so with what results.

I was diagnosed with sclc limited August 04

Had cistplatin and VP16 for four rounds and radiation to left lung, successfully resolved lung tumor at that time, but now it is back.

I am desperate for an answer.

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Irinotecan is also called CPT-11 or camptosar

There was a study in Japan that seem to indicate that CPT-11/cisplatin was better than etoposide/cisplatin but a study in the US shows about the same results for the different combinations of chemo. The researchers think that genetic difference in the Japanese have better results with CPT-11/cisplatin

Epirubicin may have effects on the heart. You might want to ask the Dr about this

It looks like this is a phase I or II trial

http://www.asco.org/ac/1,1003,_12-00263 ... 011,00.asp

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