Barb73 Posted February 20, 2009 Share Posted February 20, 2009 http://www.cnn.com/2009/HEALTH/02/19/cu ... r.vaccine/ ARTICLE: . . . . . . . . . Terminal lung cancer patients are living longer thanks to the world's first registered lung cancer vaccine, a leading Cuban scientist says. Dr. Gisela Gonzalez has spent years researching the vaccine which the Cuban government approved for the use of the general public last year. Gonzalez and her team have worked on developing the CimaVax EGF vaccine at the Cuban Center of Molecular Immunology since the early 1990s. She says all those years of hard work have finally paid off as trials show that Cubans with lung cancer are living a little longer after having the vaccine. "One of my early patients was a 32-year-old man when he started taking the vaccine. I had a son that age," the scientist told CNN. "Now he's 35. He's living and working. He visited us the other day and said he's thinking about having kids." Gonzalez says that more than 700 patients have received the vaccine over the years, many of them in seven clinical trials in Cuba, Canada and the UK. More than 400 advanced lung cancer patients received the Vaccine CimaVax EGF in the trials, according to the Latin American News Agency. The trials showed that the drug extended the life of terminal patients by an average of four months, and in some cases several years, compared with those patients who only received traditional therapies. Younger patients tended to fare better. "It has the potential to be very important," according to Dr. Howard Burris, director of drug development at the Sarah Cannon Research Institute in Nashville, Tennessee. He said the results were comparable to those being produced by two other lung cancer vaccines, GVAX and BLP 25, being developed in the United States. "Larger trials will show there are subsets that it's very good for and for others it's not relevant," he said. CimaVax EGF does not prevent or cure lung cancer. It is a therapeutic vaccine which stimulates the patient's body to make an antibody against the epidermal growth factor (EGF), which is a key driver causing lung cancer cells to grow. It is used in conjunction with chemotherapy and radiation therapy which reduce the size of the initial tumor. "With this kind of product, maybe cancer, advanced cancer, can be treated like any other chronic disease like diabetes," Dr. Gonzalez said during a recent tour of her modern laboratory in Havana. Medical services, even the most costly, are provided free of charge in communist Cuba. CimaVax EGF is now part of routine treatment for advanced lung cancer patients. Experts say that success is due in large part to a focus on preventative medicine and a very local approach to health that includes thousands of neighborhood physicians. Cuba has also developed a formidable biotechnology industry championed by Fidel Castro as early as the 1980s. Doctors here developed vaccines for Meningitis B and Hepatitis B which are now being used in a number of countries. Medical tourism is also on the rise, attracting paying patients from abroad. Dr. Gonzalez said CimaVax EGF has sparked a lot of interest internationally. She has advised foreign patients interested in the vaccine to seek approval from their national regulatory agencies to use it in their home country. She said two patients, one from Australia and one from Argentina, have already succeeded in doing so. In December, a lung cancer patient from Australia Liz Simon, wrote on a lung cancer forum Lungevity "Well it's actually arrived. After negotiations over six months, the CimaVax vaccine has actually arrived in Brisbane." Simon wrote that she was undergoing radiation treatment and would have to wait four weeks after that before starting the vaccine. "The vaccine's bona fides will be checked out before I start. And I will be using it under scientific conditions so that we can judge its efficacy. So let's see - I am happy to...become the resident guinea pig," she added. The Cuban team is now starting a clinical trial in Malaysia and hopes to begin others in China, India and Peru. Dr. Burris said an article last year by the Cuban doctors in the Journal of Clinical Oncology made a big splash in the scientific community, injecting new enthusiasm into U.S. research on the topic. "It's hard to get an antibody response once you've had chemotherapy," he said. "So if you have a vaccine and it works even half the time, that's pretty fabulous." . . . . . . . . . (CNN, Vital Signs, Article by Shasta Darlington, February 19, 2009) Disclaimer: The information contained in these articles may or may not be in agreement with my own opinions. They are not being posted with the intention of being medical advice of any kind. Quote Link to comment Share on other sites More sharing options...
jaminkw Posted February 20, 2009 Share Posted February 20, 2009 Good article Barbara. Thanks. The only downside for many of us is that it doesn't sound like it's effective if you've had chemo. Wonder if that's true for other vaccines being tested. Judy in Key West Quote Link to comment Share on other sites More sharing options...
Barb73 Posted February 20, 2009 Author Share Posted February 20, 2009 That's a very good question, Judy. Someone may have the answer to that. I'll keep looking. Barbara Quote Link to comment Share on other sites More sharing options...
RandyW Posted February 20, 2009 Share Posted February 20, 2009 It is used in conjunction with chemotherapy and radiation therapy which reduce the size of the initial tumor. "With this kind of product, maybe cancer, advanced cancer, can be treated like any other chronic disease like diabetes," Dr. Gonzalez said during a recent tour of her modern laboratory in Havana. The trials are now being started In MAlaysia right now and if the government ever ends the Cuban Embargo, We could be lucky enough to get this trial going!!! Quote Link to comment Share on other sites More sharing options...
Barb73 Posted February 21, 2009 Author Share Posted February 21, 2009 The trials are now being started In MAlaysia right now and if the government ever ends the Cuban Embargo, We could be lucky enough to get this trial going!!! So true, Randy. Barbara Quote Link to comment Share on other sites More sharing options...
jaminkw Posted February 21, 2009 Share Posted February 21, 2009 "It's hard to get an antibody response once you've had chemotherapy," he said. "So if you have a vaccine and it works even half the time, that's pretty fabulous." Randy, your post made me go back and take a second look at what I had read. I think I read it wrong. Instead of saying it doesn't work if you've had chemo, it says it does work half the time. Thanks. Judy in Key West Quote Link to comment Share on other sites More sharing options...
Barb73 Posted February 21, 2009 Author Share Posted February 21, 2009 Judy and Randy, The part that made me feel positive about the article regarding the vaccine was where it mentioned the "possibility" of advanced lung cancer being treated as a chronic disease, such as diabetes. That would be hopeful for those for whom it would be effective. Barbara Quote Link to comment Share on other sites More sharing options...
Ellen in PA Posted February 21, 2009 Share Posted February 21, 2009 Hi Randy and others. Thanks for posting this, Randy. I've been following it for several months and I believe some Americans have already gone to Cuba for the vaccine. Just a FYI: It is NOT illegal for Americans to go to Cuba. What is illegal is for us to spend money there but that's actually pretty hard to do (since there's not exactly an abundance of things you'd want to buy and since medical care is entirely free for everyone, even tourists). My husband and I went there as tourists about 20 years ago (via Montreal, since you can't fly there from here) and my husband went again about 5 years later (again thru Montreal) at the invitation of the Cuban Ministry of Education. There were no problems with either trip. (Of course, if you happen to have relatives in Cuba, I think you can even fly there from Florida.) By the way, the no-spending-money-there is a Treasury Dept law -- and I would think/hope the Treasury Dept has bigger problems on its collective mind now than prosecuting American cancer patients who paid for their meals in Cuba while getting (free and cutting edge) medical treatment. Ellen Quote Link to comment Share on other sites More sharing options...
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