Deb W Posted June 5, 2020 Share Posted June 5, 2020 Does anyone have the MET biomarker? If so, I'd love to hear from you. Link to comment Share on other sites More sharing options...
MarieE Posted June 11, 2020 Share Posted June 11, 2020 We just found out that my husband does. Should know more about next steps after talking with the doctor today. Link to comment Share on other sites More sharing options...
jack14 Posted June 12, 2020 Share Posted June 12, 2020 Seems it is rather rare. Link to comment Share on other sites More sharing options...
MarieE Posted June 12, 2020 Share Posted June 12, 2020 8 hours ago, jack14 said: Seems it is rather rare. From what I have read so far it sounds like 2 to 3%. So yes, but it seems related to more aggressive lung cancer. Link to comment Share on other sites More sharing options...
jack14 Posted June 12, 2020 Share Posted June 12, 2020 I wonder if there is any significance in one having a MET amplication and taking Keytruda. Since it is a drug that targets PDL-1 protein? Or am I off track.... Link to comment Share on other sites More sharing options...
MarieE Posted June 12, 2020 Share Posted June 12, 2020 Can't answer your specific question, although until the MET mutation was identified for my husband, the plan was for chemo plus Keytruda and then radiation. All of that changed when the NGS report was received. We are waiting to hear back from insurance regarding Tabrecta but in the meantime he will be starting radiation next week to help reduce the size of the mass on his chest wall that has grown a lot and become increasingly painful. The doctor also said there are several other MET targeting drugs in the pipeline so hopefully there will be other options if my husband can't tolerate Tabrecta or if it is not effective. His oncologist felt that trying the targeted therapies was a much better option for my husband than going with chemo/immunotherapy. He does have high PDL-1 and high Tumor Mutation Burden. He also has several other abnormalities that were detected both on the two tumor reports as well as the GUARDANT 360 liquid biopsy assay. Link to comment Share on other sites More sharing options...
Dragonmew Posted July 24, 2020 Share Posted July 24, 2020 My mom is having Met 14 skipping. She’s on Capmatinib. Link to comment Share on other sites More sharing options...
Rower Michelle Posted August 19, 2020 Share Posted August 19, 2020 For the MET Crusaders- You might want to check out Dr Levy’s remarks from this week’s GO2FOUNDATION Living Room. He talks about the direction of targeted therapies & blood biopsies Link to comment Share on other sites More sharing options...
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