Andrea B. Posted March 22, 2004 Share Posted March 22, 2004 Hi All, Well the bad news continues for us...my mom is not eligible for the GVAX vaccine due to the fact that there is not cancer in the fluid around her lung. Can't believe I would ever wish for cancer to be present!!! Also, the cancer in her liver is rapidly progressing and one of her liver blood counts is high. So right now the only other option to pursue is another chemo. Her oncologist mentioned trying Navalbine, but I am wondering if any others of you have suggestions on ones to try. Thanks so much! This site is a saving grace for me. Blessings to each of you. Andrea B. Quote Link to comment Share on other sites More sharing options...
KatieB Posted March 23, 2004 Share Posted March 23, 2004 Andrea, I don't have any real answers for you- I just wanted you to know that I am praying real hard for you guys and that I hope youhave some answers and a new treatment (that WORKS quickly) soon. God bless. We are all here for you. Quote Link to comment Share on other sites More sharing options...
kimblanchard Posted March 23, 2004 Share Posted March 23, 2004 Andrea, Is the Gemzar/Navalbine combination an alternative?? Gemzar is one of the more tolerable chemos and is often paired with Navalbine. Gemzar held Bill stable for many months. Blessings to you and dear mom, Peg Quote Link to comment Share on other sites More sharing options...
Andrea Posted March 23, 2004 Share Posted March 23, 2004 Andrea, The only chemo I have had experience with is gemzar/carboplatinum. It worked so far for my mom. Saying lots of prayers Quote Link to comment Share on other sites More sharing options...
john Posted March 23, 2004 Share Posted March 23, 2004 The article below is about combined Gemzar (gemcitabine) /Navalbine (vinorelbine) http://www.ncbi.nlm.nih.gov/entrez/quer ... t=Abstract Phase II study of gemcitabine and vinorelbine combination chemotherapy in patients with non-small-cell lung cancer not responding to previous chemotherapy. Chen YM, Perng RP, Lee CS, Lin WC, Tsai CM, Whang-Peng J. Chest Department, Taipei Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taipei 112, Taiwan, ROC. Both gemcitabine and vinorelbine are new anticancer drugs that have shown activity in the treatment of chemonaive non-small-cell lung cancer (NSCLC). Their role in the second-line treatment of NSCLC is less clear. We conducted a phase II study of gemcitabine and vinorelbine combination chemotherapy in patients with NSCLC who had not responded to previous platinum-based chemotherapy, to assess the response and toxicity of this regimen. Seventeen patients were enrolled from September 1998 to February 2001. Treatment consisted of vinorelbine 20 mg/m2 and gemcitabine 800 mg/m2 intravenous infusion on days 1, 8, and 15 every 4 weeks. Sixty-five cycles of treatment were given, with a median of four cycles. All patients were evaluable for the toxicity profile, and 16 patients were evaluable for the response rate. The major toxicity was myelosuppression. Grade III or IV neutropenia occurred in 9 patients (52.9%) during treatment. Febrile neutropenia occurred in only 1 patient (5.9%). Grade III anemia and thrombocytopenia occurred in two and three patients, respectively. Other toxicities were few and mild in severity. After 2 cycles of treatment, 5 of 16 patients (31.3%) had a partial response (95% CI 8.6-64%). The median time to disease progression was 4.6 months and the median survival was 8.3 months. The 1-year survival rate was 34.3%. In conclusion, gemcitabine and vinorelbine salvage chemotherapy produces a relatively high response rate, low toxicity profile, and good survival in Chinese patients with NSCLC who have not responded to previous platinum-based chemotherapy. Further study is needed to confirm its activity. Publication Types: Clinical Trial Clinical Trial, Phase II There are other clinical trials for nsclc that is refractory http://www.clinicaltrials.gov/ct/search ... refractory MAC-321 is a new chemo. Quote Link to comment Share on other sites More sharing options...
shelliemacs Posted March 23, 2004 Share Posted March 23, 2004 Andrea, I too have no answers, but your mom is always being prayed for here. Quote Link to comment Share on other sites More sharing options...
MO_Sugar Posted March 23, 2004 Share Posted March 23, 2004 Prayers and good wishes are all I can offer. God Bless, MO Quote Link to comment Share on other sites More sharing options...
Andrea B. Posted March 23, 2004 Author Share Posted March 23, 2004 Thank you from the bottom of my heart for the valuable information and the prayers. John, thank you so much for your post! I think my mom will be trying the Gemzar/Navelbine combo. I appreciate all of you so much!!! Blessings to each of you. Quote Link to comment Share on other sites More sharing options...
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