RandyW

Sending prayers from the Carolinas

http://www.uwmedicine.org/PatientCare/I ... rvices.htm This is University Of Washington Links? Contact UW Medicine Harborview Medical Center UW Medical Center UW Physicians UW School of Medicine UW Medicine Web Site UW Directory Assistance -------------------------------------------------------------------------------- Harborview Medical Center Harborview Medical Center Operator Tel: 206-731-3000 TTY: 206-731-2800 Clinic Information 206-731-3754 Community Relations 206-731-3041 Health Coverage Services 206-731-3084 Human Resources 206-731-3233 Parking Information 206-731-3254 Patient Information 206-731-3300 Patient Relations 206-731-5000 Release of Information 206-521-1573 More Phone Numbers... -------------------------------------------------------------------------------- UW Medical Center UW Medical Center Operator Tel: 206-598-3300 TTY: 206-598-4002 versity Of Washington Link

http://www.seattlecancerwellness.com/ad ... organ.html This is a link to a cancer center in seattle Established patients and providers, please call 800-321-9272 I do not know if this is possible but a phone call can not hurt. If you don't ask you will never know. Good luck and many prayers for you and your family

Deb took Immodium for Diarhea but other symptoms are new to me As I recall She had dry skin and the Acne rash as she called it. Onc put her on Tarceva as a stabilizer drug to maintain rather than cure or kill cancer. Call Dr. to check synptoms. Low WBC Counts mean more susceptible to any disease and harder to recover. CALL DR. ASAP to be sure it is not a bug.

Praying for good news and better days ahead with the Alimta.

Saying Prayers from the Carolina Skies

Many prayers For y' all from under the Carolina Grey skies today

Dear Karen and Ken Take Pictures for memories. enjoy every second you can get right now. No stress on anyone. Laugh at the good times together.enjoy life to the fullest while able to. I know this is tough to think about. I went through the passing away 1 month ago. Still hurts a lot. share funny stories and enjoy all the love and comfort that your Family is bringing by coming together right now.Much Love, Joy, Prayers, and peace for all of your Family right now

http://www.mgh.harvard.edu/cancer/clini ... finder.asp

http://clinicaltrials.mayo.edu/mayo_cli ... g%20Cancer

http://cancer.ucsd.edu/cto/study_list.asp?Alpha=L#TTop

http://www.clevelandclinic.org/cancer/t ... sease=Lung

I know it hurts and it will for a while now. My condolences to you and your family. Lost my wife 1 month ago tomorrow. Let the grief come out whenever and whereever it happens. it is the best thing for you. My prayers and condolences to You and your Family.

Saying extra prayers for Teri and her Family

Will say extra prayers toinite for you guys and much good Luck to you in recovering

Glad to hear you are doing as ok as ok can do right now. Will say prayers

You Can Post it in the Clinical research and medical forum. Good Luck with the surgery. Will say a prayer for you and your family.

Praying for great results with few side effects as possible. You guys are doing great I think. Much Love Joy and prayers for you

Novel Cancer Therapy Developed From Basic Research Main Category: Cancer/Oncology News Article Date: 18 Feb 2006 - 5:00am (UK) Cancer researcher Professor Axel Ullrich, a director at the Max Planck Institute of Biochemistry in Martinsried, Germany, already showed at the beginning of the 1990s that blocking blood vessel development in a tumour slows down its growth, and shrinks its tissue. This fundamental principle led to the development of SUTENT®, whose active ingredient is Sunitinib. SUTENT® was recently approved for clinical use in the United States, and it is expected to be brought onto the German market this year. When particular growth factors are bound to specific receptors on the surface of a cell, this can cause the cell to propagate itself and build certain tissue similar to blood vessels. Worldwide, research into receptors has focused on a special class of proteins, called tyrosine kinases. They are responsible for causing the received signal to be transduced through a long signalling cascade into the nucleus, triggering cell division and multiplication. Signalling cascades are absolutely necessary, if various tissues - like blood vessels, nerve tissue, and connective tissue - are to be built up during the development of an organism and in the process of tissue regeneration. Research has focussed on these tumour cell signalling cascades, because in cancers they are often disturbed. If there were a way to block growth factors, or the receptors on the cellular surface from tumour cells, that could lead to targeted therapies against cancers. Already in the 1980s, cancer researcher Axel Ullrich, then a scientist at Genentech (USA), working with colleagues in the UK and Israel, succeeded in describing the structure and function of a receptor for epidermal growth factor (EGF). Since then, tyrosine kinases and various growth factors have been at the focus of research and development of therapies against tumours. Also, over a decade ago, a team led by Ullrich discovered that by interrupting the oxygen and nutrient supply to tumour cells, it is possible to inhibit cancer development. The Max Planck scientists showed that tumour tissue just a few cubic millimetres in size can create vascular endothelial growth factor (VEGF), which triggers blood vessel development. Ullrich found some of the most important evidence in research on animals, conducted with colleagues Birgit Millauer and the late Werner Risau, formerly of the Max Planck Institute of Neurobiology. There is a receptor specific to VEGF, called Flk-1/VEGFR2, found only in endothelial cells which are the building stones of new blood vessels. When Flk-1/VEGFR2 is made inoperative, this blocks the development of tumours. If no blood vessels are created in tumour tissue, the tumour fails to grow. This discovery led to the invention of what are called angiogenesis inhibitors (angiogenesis is the process of blood vessel formation). Ullrich and the Max Planck Society, in co-operation with New York University, founded SUGEN, Inc. in California in 1991. SUGEN is the first biotechnology company with roots in the Max Planck Society. The firm developed chemical substances which block Flk-1/VEGFR2 in endothelial cells. At the end of the 1990s SUGEN was taken over by Pharmacia, which itself was bought by Pfizer in 2003. Development of the project continued at Pfizer. SUTENT® (active ingredient Sunitinib) has now reached the market as a multi-targeted tyrosine kinase inhibitor, which blocks both the building of blood vessels in tumours as well as other illness-related enzymes in tumour cell signalling networks. Clinical studies with GIST patients looked into their ability to tolerate Sunitinib, as well as its effectiveness on them. Some of these patients had already been treated with Imatinib, but their tumours continued to develop. Others were not able to tolerate Imatinib at all. Still other patients had advanced renal cell carcinoma with failed available treatment. In the case of the GIST patients, it took four times longer for tumours to renew growth when treated with Sunitinib, compared to the placebo group. Patients with advanced renal cell carcinoma saw a shrinking of the tumour; in 26 to 37 percent of them, the tumour shrunk to at least half its size. Sunitinib has not yet been approved in Germany, but approval and market entry are expected in this year. Sunitinib is administered after diagnosis. A large number of further clinical studies has shown that Sunitinib has multiple effects on tumour cells and can thus be defined as a novel "multi-targeted" drug. Sunitinib is being tested now, as well, on patients with advanced forms of bladder cancer, breast cancer, cervical cancer, colon cancer, esophageal cancer, head and neck tumours, liver cancer, lung cancer, melanoma, ovarian cancer, pancreatic cancer, prostate cancer, and testicular cancer. The studies are in various stages of clinical trials (phases I through III), and most of them are being carried out in combination with other therapies. Ullrich is very pleased with the quick approval of SUTENT®. He says, "Already before approval, 1,700 patients could be treated with the new preparation, thanks to the Accelerated Approval Process. Naturally, we're happy that our research led so quickly to application in cancer therapy. Each year, 390,000 people in Germany alone, and several million worldwide, become ill with cancer. Every fourth death is related to a tumour. We can improve the length and quality of patients' lives by treating them with very specific drugs, which attack a variety of characteristics of tumour cells. Therapy with multi-targeted substances which block signal transduction in tumour cells is a new breakthrough in the war on cancer. They attack critical cancer cell functions in multiple ways and are well tolerated by patients." This is the second time that Ullrich has played a leading role in the development of a successful cancer therapy. Seven years ago, his research led the breast-cancer therapy Herceptin® to be brought to the market by Genentech. In contrast to SUTENT®, Herceptin® attacks the efforts of genetic alterations in the cells of certain forms of breast and ovarian cancer. It blocks the receptor Her2/neu in these cells, which thereby stop growing and become more specific to the immune system. Since then, Ullrich and his colleagues have applied for some 60 patents - this makes him one of the most successful cancer researchers in the world. He has founded four biotechnology companies, three of them on the campus in Martinsried. Since 1988 he has led the Department of Molecular Biology at the Max Planck Institute of Biochemistry. Last year he established the "OncoGenome Project" in Singapore's Centre for Molecular Medicine, a member of the Agency for Science, Technology, and Research (A*STAR). ### An affiliated company to the Max Planck Society, Garching Innovation, is responsible for the further development, marketing, and patenting of products borne of the results of basic Max Planck research. Since 1979, Garching Innovation has looked after about 2,443 inventions and concluded 1,472 utilization agreements. To date, the total returns amount to about 181 million euros, half of which originate abroad. Ullrich and his colleagues' patents are among those looked after by Garching Innovation. Jörn Erselius, managing director of Garching Innovation, says "SUTENT®'s success story is an impressive demonstration of Garching Innovation's strengths: combining out-licensing with founding companies." Contact: Prof. Axel Ullrich diehl@biochem.mpg.de Max-Planck-Gesellschaft

Saying prayers and congrats on good news

Friday, February 3rd, 2006 Send Me Your Health Care Horror Stories... an appeal from Michael Moore Friends, How would you like to be in my next movie? I know you've probably heard I'm making a documentary about the health care industry (but the HMOs don't know this, so don't tell them — they think I'm making a romantic comedy). If you've followed my work over the years, you know that I keep a pretty low profile while I'm making my movies. I don't give interviews, I don't go on TV and I don't defrost my refrigerator. I do keep my website updated on a daily basis (there's been something like 4,000,000 visitors just this week alone) and the rest of the time I'm... well, I can't tell you what I'm doing, but you can pretty much guess. It gets harder and harder sneaking into corporate headquarters, but I've found that just dying my hair black and wearing a skort really helps. Back to my invitation to be in my movie. Have you ever found yourself getting ready to file for bankruptcy because you can't pay your kid's hospital bill, and then you say to yourself, "Boy, I sure would like to be in Michael Moore's health care movie!"? Or, after being turned down for the third time by your HMO for an operation they should be paying for, do you ever think to yourself, "Now THIS travesty should be in that 'Sicko' movie!"? Or maybe you've just been told that your father is going to have to just, well, die because he can't afford the drugs he needs to get better – and it's then that you say, "Damn, what did I do with Michael Moore's home number?!" Ok, here's your chance. As you can imagine, we've got the goods on these bastards. All we need now is to put a few of you in the movie and let the world see what the greatest country ever in the history of the universe does to its own people, simply because they have the misfortune of getting sick. Because getting sick, unless you are rich, is a crime – a crime for which you must pay, sometimes with your own life. About four hundred years from now, historians will look back at us like we were some sort of barbarians, but for now we're just the laughing stock of the Western world. So, if you'd like me to know what you've been through with your insurance company, or what it's been like to have no insurance at all, or how the hospitals and doctors wouldn't treat you (or if they did, how they sent you into poverty trying to pay their crazy bills) ...if you have been abused in any way by this sick, greedy, grubby system and it has caused you or your loved ones great sorrow and pain, let me know. Send me a short, factual account of what has happened to you – and what IS happening to you right now if you have been unable to get the health care you need. Send it to michael@michaelmoore.com. I will read every single one of them (even if I can't respond to or help everyone, I will be able to bring to light a few of your stories). Thank you in advance for sharing them with me and trusting me to try and do something about a very corrupt system that simply has to go. Oh, and if you happen to work for an HMO or a pharmaceutical company or a profit-making hospital and you have simply seen too much abuse of your fellow human beings and can't take it any longer – and you would like the truth to be told – please write me at michael@michaelmoore.com. I will protect your privacy and I will tell the world what you are unable to tell. I am looking for a few heroes with a conscience. I know you are out there. Thank you, all of you, for your help and your continued support through the years. I promise you that with "Sicko" we will do our best to give you not only a great movie, but a chance to bring down this evil empire, once and for all. In the meantime, stay well. I hear fruits and vegetables help. Yours, Michael Moore michael@michaelmoore.com www.michaelmoore.com

I Can relate the situation Feb 16 is my wedding anniversary. Many prayers for your family in this troubling time. MAny condolences also. Be Strong.

My Late wifes Oncologist would ask for any leftover pills of any sort to be returned to his office so he could give them to patients who had problems paying for prescriptioons. Daily vitamins, Supplemeents, Pain Management or anything else possible. You may want to ask if they do this at your facility. If not Maybe they could start something to help out those who need the assistance.

Many Prayers for you and your family at this time and always.

3 Weeks For Me and Started Valentines Day with a trip to the cemetary To see deb. 16th Would Be our 9th anniversary. Everyone here is right on and have helped me a lot. This is the A most difficult Time for all of us I think But You Are doing the right things right now. don't keep your grief bottled up, let it out. Many prayers for you from under the Carolina Blue Skies this Morning.