Hi Linda, Carbo/Gemzar was the first line treament for my mom and she did very well with it. Minimal side effects, no hair loss.....Really just some fatigue that they took care of with Aranesp for her low red count....She went out to lunch and dinner with friends, shopping, etc. After 6 cycles she had a definite decrease in the size of her mass, but they decided to roll her into the next line to try and shrink it some more. Good luck to you. Shelley