SDianneB Posted November 16, 2005 Share Posted November 16, 2005 Michael Jackson, Robert Blake, and Di. Ha. KIDDING!! Not that kind of trial for me! Got the results of my CT scan following cycle #10 of oral Topo, and it worked amazingly well except for one thing. First though, the really good news is that my chest - both sides - is free of cancer, and the radiation scarring is actually healing gradually, so my chest looks better and better with each scan. Also, there is nothing new showing up which is a very good thing. The problem is the pancreas that has a small mass that developed a resistance to the Topo. Strange, since everything else was responding so well! Actually, there is necrotic (dead) tissue there, so it was responding, but wants to keep growing, albeit very slowly. So, the Onc. felt that more Topo would just leave the door wide open for this spot, and put me into another trial. This one is a real trial though, as opposed to the Topo which was a study of the efficacy of oral vs. IV administration. This drug doesn't really have a name -- they call it Synta (after the company that makes it) STA-5312. Here's a URL where you can find a little about it and the trial: http://clinicaltrials.gov/ct/show/NCT00088101?order=1 There is something in it that prevents it being ejected by "bad" cells, so it hangs in there and zaps the cancer. The Onc. is fired up about it, so I was good to go on her recommendation. Next Monday (Nov. 21) I have what's called a "MUGA" - yep. Sounds just like it looks! (Like what we'd call a "mugger" here in the south!) I'll also have to finally give in an have a port put in, but even that's ok, because I was extremely fortunate during the 18 months since this all started to have only had 4 IVs of Carboplatin - the rest was all oral. So, it's going into strange territory one more time. At least if I get through the MUGA! That tests the flow in and out of the heart, and so far, my heart function is the most healthy thing about me! The Research nurse and Onc. are very positive about this, and so am I. I won't start the actual infusion until the week after Thanksgiving, and won't know about the dosage I'll get until it all starts, but will keep you filled in. It's a M-W-F infusion, week off, M-W-F infusion, week off cycle -- two of those and then a scan. Besides all that, my blood counts were terrific. In a week, my platelets had tripled, and with this week and next week off chemo, the Onc. says I'll probably be back to normal in a few days. I'm strong as an ox -- good genes I guess! I'm still feeling good and still working too. I've had some minor discomfort when I sleep in one position for too long or twist myself the wrong way, and I'm taking Protonix and Aleve twice a day which is keeping that all under control. Once I find out more, I'll let you guys know. I'm just so grateful to be in such good hands, and in one of the few places in the country where I can have access to a drug like this. Di Quote Link to comment Share on other sites More sharing options...
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