RandyW

DCA goes back a few years and so is this story as well... DCA is non-patentable as a compound, though a patent has been filed for its use in cancer treatment.[20] Research by Evangelos Michelakis has received no support from the pharmaceutical industry.[21] Concerns have been raised that without strong intellectual property protection, the financial incentive for drug development is reduced, and therefore obtaining sufficient funds to conduct clinical trials presents difficulty.[12][14][15][22] However, other sources of funding exist; previous studies of DCA have been funded by government organizations such as the National Institutes of Health, the Food and Drug Administration, the Canadian Institutes of Health Research and by private charities (e.g. the Muscular Dystrophy Association). Recognizing anticipated funding challenges, Michelakis's lab took the unorthodox step of directly soliciting online donations to fund the research.[23] After 6 months, his lab had raised over $800,000, enough to fund a small Clinical Phase 2 study. Michelakis and Archer have applied for a patent on the use of DCA in the treatment of cancer.[20][24] On 24 September 2007, the University of Alberta's Department of Medicine reported that after the trial funding was secured, both the Alberta local ethics committee and Health Canada approved the first DCA clinical trial for cancer.[25] This initial trial was relatively small with enrollment of up to 50 patients. The trial was completed in August 2009.[26] In May 2010 the team published a press release[27] stating no conclusions could be drawn as a result of the trial. A paper describing the results was published[28] but not linked from the press release. Only five patients had been treated with the drug during the trial. In May 2011, online reports[29] suggested that the Alberta group had released new data which the media "had not reported". However, this appeared to be caused by confusion between dates (the previous update was May 2010[30]) and cancer charities moved quickly to counter these rumours,[31][32] which were subsequently covered in New Scientist magazine.[33] The use of this compound as an anti-cancer agent has been patented.[34] Cancer cells generally express increased glycolysis, because they rely on anaerobic respiration that occurs in the cytosol (lactic acid fermentation) rather than oxidative phosphorylation in the mitochondria for energy (the Warburg effect), as a result of hypoxia that exists in tumors and malfunctioning mitochondria.[10][11] Usually dangerously damaged cells kill themselves via apoptosis, a mechanism of self-destruction that involves mitochondria, but this mechanism fails in cancer cells. A phase I study published in January 2007 by researchers at the University of Alberta, who had tested DCA on human[12] cancer cells grown in mice, found that DCA restored mitochondrial function, thus restoring apoptosis, allowing cancer cells to self-destruct and shrink the tumor.[13] These results received extensive media attention, beginning with an article in New Scientist titled "Cheap, ‘safe’ drug kills most cancers".[12] Subsequently, the American Cancer Society and other medical organizations have received a large volume of public interest and questions regarding DCA.[14] Clinical trials in humans with cancer have not been conducted in the USA and are not yet final in Canada, emphasizing the need for caution in interpreting the preliminary results.[14][15]

For decades, nutritionists have advised patients to reduce or eliminate their red meat consumption, citing cardiovascular disease, diabetes and colorectal cancer as reasons to abstain. Lung cancer may be next on the list. In the December 2012 issue of Annals of Oncology, researchers found that a high intake of red meat can increase a person’s lung cancer risk by as much as 35 percent. The researchers reviewed 34 studies that explored the relationship between red meat and lung cancer. After making adjustments for the patient’s smoking status, the researchers found a much higher relative risk for lung cancer in patients who had the highest red meat intake. This risk was even higher (although only by one one-hundredth of a percentage point) in patients with the highest overall meat intake. A Consolation for Meat Lovers While some lung cancer risk factors – such as a history of asbestos exposure or a genetic predisposition to the disease – cannot be changed, patients can improve their diets. And while many studies suggest that a plant-based diet is an optimal approach for cancer prevention, those who do choose to consume meat can make smarter protein selections to reduce their risk of disease. Interestingly enough, the Annals of Oncology study found an inverse association between poultry intake and lung cancer. As the patients’ consumption increased, their lung cancer risk decreased by as much as 10 percent. Poultry – especially chicken – may be a smarter choice because it is particularly low in heme iron. Salmon and flat fish such as flounder also have low concentrations of the compound. Many nutrition researchers believe heme iron is responsible for carcinogenesis. Researchers who have linked red meat to other cancers often suggest that high concentration of heme iron increases cell proliferation of all living cells – including malignant ones. Heme iron also increases the body’s formation of N-nitroso compounds. Several of these compounds are human carcinogens and may cause DNA mutations that lead to cancerous developments. Making a Place for Red Meat in a Healthy Diet Most nutritionists do recommend white meat and lean cuts for patients who do include meat in their diet. However, if patients must consume red meat, nutritionists typically recommend a maximum weekly intake of less than 330 grams (11 ounces). Little – if any – of this meat should be processed. Processed red meats include bacon, sausage, cold cuts, hot dogs and luncheon meats. Unprocessed options include steak, rack of lamb or pork chops. However, most nutrition professionals agree that these options are still less healthy than white meat, fish, or plant-based proteins such as beans and nuts.

congrats on that amazing milestone.... Prayers for Great news to come!!!

we are always here for help whenever you need us.. I am so very very sorry to read this today. Remember there is always Hope in some way or another in some form. My thoughts and prayers today and every day for peace an comfort..

there goes those darn doctors again playing god..... first off pay no attention to that part..only God knows how long we have and she don't tell us til she wants to talk and see us in person. Yep said she and we know god is a woman so... A lot of the time the waiting for the treatment to start is the hardest part of the journey in and of itself. we wait and we think too much and we cry and we get all the bad emotions out of the way. then when the treatments start the mind goes Hooray we are doing something to fix the problem and the fighting mode kicks in and beats back the fear of the unknown... for the time being a suggestion that i offer everyone is to take a look at the Good news forum and the Inspirational forum in here.. These 2 forums focus on the positive of things around here . all kinds of great news and uplifting thoughts and pryers and offerings of comfort..... On another note about the cure... right now there is no known cure 100% for Lung cancer or any cancer. Scientists and researchers are focusing on the goal of making cancer a maintainable disease first then looking for a cure. there are treatments that work towards this goal. the goal is to stay fighting in hopes of the scientists finding the treatment that works the best for keeping the disease at bay. They want to get cancer on the same level as heart disease or diabetes or a number of other treatable diseases so then they can work on finding a cure for it....

lingOL

gone from the backyard pool in Cali to a woodstove in Illinois.... Biy you have some adventures....

all 4 of us.....

who told you that crazy idea???? still do it but for a different person this year....sometimes for Deb though. Hugs and prayers to both of you wonderful ladies.... I think this might be your song Lillian .....

A bump for some insight from dean Carl RIP and always sharing some wisdom from you!!

anyone interested in a free download cookbook???

Me I am an old moderator... nice to meet You Cindy and I know Katie and Michellle!!! thanks for Intro Cindy!

more words of wisdom tonight...... thanks Chacha!!!

bumpin for some love tonight... love this one....

feel the need to share this one..... Like it and I know Lillian would not mind.....

awesome thanks for sharing this one!!!!

I can not offer much but hope someone will come along that can!!!

every once in a while I go through and find some encouraging gems..... You never know....... hugs to all of my friends.

oh and also feeding tubes which can be removed later on... they are most unpleasant though and should be last resort....

I have been reading and following along as you all have been posting.. Lots of great advice and info coming to you.. The Multivitamins are good but can not fix the weight problem. What you need to find out is if you can get meals or snacks for whenever she is hungry.. weight loss suddenly and rapidly is not good for anyone and can cause what is known as Cachexia in patients.. this is also known as muscle loss.. Not a good thing.. Fi you can not have food or snacks for her due to hospital rules is there a possibility of having something like what we have in the US also know as Ensure on hand? these are basically protein shakes designed to help hunger issues and add vitamins and minerals to a diet or also as a meal substitute. another option is to get a shake of some sort from Hospital commissary if you can not get food and add a couple of spoonfuls of Protein powder similar to what body builders use from a Drug store pharmacy or possibly a grocery store. you could also get folks if hospital allows it to bring soft fruits or yogurt of some sort when they come to visit for her... Just some ideas on dealing with the weigh issues....

Eric put it in your pocket and you will have that special connection anyways... No one will know it is there but you and Linda..... Hugs and prayers for you and Family and Friends. glad your minister was so very accommodating for you!!

Pain management is priority number one in all cancer cases.. is there any other options besides patches and oxycodone without doing further damage to his system? My late wife was on Hydrocodone for breakout pain and oxy codone for regular pain. Not sure how that would play out with the patches of course though. I hope you get some answers and he gets the needed pain relief... thought and prayers always...

5 years ago before the Air started there was the Gratitude...

Interesting song I found..

thanks Frank !! RIP Friend.. Seems quite appropriate about now in a lot of ways....